Title:
成長ホルモンの増進された経粘膜送達のための組成物および方法
Document Type and Number:
Japanese Patent JP2007500243
Kind Code:
A
Abstract:
Pharmaceutical formulations are described comprising at least one growth hormone and one or more intranasal delivery-enhancing agents for enhanced nasal mucosal delivery of the growth hormone. In one aspect, the intranasal delivery formulations and methods provide enhanced delivery of growth hormone to the blood plasma, for example, by yielding a peak concentration (Cmax) of the growth hormone in an hepatic portal vein or a blood plasma of the subject that is 20% or greater compared to a peak concentration of the growth hormone in the hepatic portal vein or the blood plasma of the subject following administration to the subject of a same concentration or dose of the growth hormone to the subject by subcutaneous injection. Exemplary formulations and methods within the invention utilize human growth hormone as the hormone.
Inventors:
Key, Stephen Sea
De Myreles, Jorge See
Gupta, Marini
Vangala, siam
De Myreles, Jorge See
Gupta, Marini
Vangala, siam
Application Number:
JP2006533559A
Publication Date:
January 11, 2007
Filing Date:
June 01, 2004
Export Citation:
Assignee:
NASTEC Pharmaceutical Company, Inc.
International Classes:
A61K38/27; A61K9/00; A61K9/127; A61K9/14; A61K9/72; A61K38/24; A61K47/04; A61K47/10; A61K47/12; A61K47/18; A61K47/34; A61P3/00; A61P5/00; A61P5/02; A61P9/04; A61P9/10; A61P37/02
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri