Title:
グランザイムB阻害のための組成物および方法
Document Type and Number:
Japanese Patent JP2009509979
Kind Code:
A
Abstract:
The present invention is related to the discovery that serpina3n, a secreted protein, binds to and inhibits granzyme B activity. The invention thus provides cells that include a polynucleotide encoding a granzyme B inhibitory serpin, pharmaceutical compositions including a granzyme B inhibitory serpin or a polynucleotide encoding a granzyme B inhibitory serpin, methods for treating a patient in need of immunosuppression by administration of a granzyme B inhibitory serpin, and methods of transplanting cells (e.g., islet cells) expressing a granzyme B inhibitory serpin.
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Inventors:
Lajotte Ray V.
Blakely Earl.Chris
Corbat Greg
Lord Sarah J.
Sipion Simonetta
Carmine-Simmen Katia
Giuliani Fabrizio
Blakely Earl.Chris
Corbat Greg
Lord Sarah J.
Sipion Simonetta
Carmine-Simmen Katia
Giuliani Fabrizio
Application Number:
JP2008532546A
Publication Date:
March 12, 2009
Filing Date:
September 26, 2006
Export Citation:
Assignee:
University of Alberta
International Classes:
A61K38/55; A01K67/027; A61K31/7088; A61K35/12; A61K35/23; A61K35/34; A61K35/39; A61K35/407; A61K35/42; A61K35/60; A61K48/00; A61L27/00; A61P3/10; A61P9/00; A61P19/02; A61P25/00; A61P29/00; A61P37/06; A61P43/00; C12N15/09; C12N5/10
Domestic Patent References:
| JP2005060379A | 2005-03-10 | |||
| JP2005120070A | 2005-05-12 | |||
| JP2005522430A | 2005-07-28 | |||
| JPH09512423A | 1997-12-16 |
Foreign References:
| WO2005026124A1 | 2005-03-24 | |||
| WO2004113523A1 | 2004-12-29 |
Other References:
JPN6012008035; Ｍｏｌ．Ｃｅｌｌ．Ｂｉｏｌ． Ｖｏｌ．１８, 1998, ｐ．６３８７-６３９８
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue