Title:
ＥＴＢＲ活性化に関連した癌を治療するための組成物及び方法
Document Type and Number:
Japanese Patent JP6903055
Kind Code:
B2
Abstract:
The description provides compositions and methods for treating ETBR-related cancer. In certain aspects, the description provides a delivery system for the controlled, systemic release of at least one of ETBR antagonists, caspase-8 inhibitors, or a combination thereof, optionally including an ETAR antagonist, an anti-PD-1 antibody, a bRAF inhibitor, niacinamide or a combination thereof. The compositions described are useful for the treatment of certain cancers, including, e.g., breast cancer, malignant melanoma, squamous cell carcinoma, glioblastoma, as well as others. In addition, the description provides a delivery system for the controlled release of at least one of ETBR antagonists, caspase-8 inhibitors or a combination thereof, optionally including at least one of an ETAR antagonist, an anti-PD-1 antibody, a bRAF inhibitor, niacinamide, or a combination thereof, to the central nervous system that are useful for treating cancers that have spread to the brain.
Inventors:
Sumaya Jamal
Application Number:
JP2018526489A
Publication Date:
July 14, 2021
Filing Date:
August 03, 2016
Export Citation:
Assignee:
NB Therapeutics, Inc.
International Classes:
A61K9/08; A61K45/06; A61K9/127; A61K9/14; A61K31/4025; A61K31/437; A61K31/44; A61K31/455; A61K31/506; A61K38/06; A61K38/12; A61K47/14; A61K47/20; A61K47/24; A61K47/28; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/44; A61P35/00; A61P35/04; A61P43/00; C07K5/08; C07K7/08; C07K7/64; C07K16/28
Other References:
Cancer Research,2012年,Vol.72,No.19,pp.4909-4919
Proc.Natl.Acad.Sci.USA,1999年,Vol.96,No.20,pp.11496-11500
癌と化学療法,2013年,Vol.40,No.1,pp.19-25
Molecular Cancer Therapeutics,2014年,Vol.13,No.6,pp.1599-1610
Cardiovascular Drug Reviews,2002年,Vol.20,No.1,pp.53-66
Proc.Natl.Acad.Sci.USA,1999年,Vol.96,No.20,pp.11496-11500
癌と化学療法,2013年,Vol.40,No.1,pp.19-25
Molecular Cancer Therapeutics,2014年,Vol.13,No.6,pp.1599-1610
Cardiovascular Drug Reviews,2002年,Vol.20,No.1,pp.53-66
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe