Title:
Trp-p8発現に関連する疾患の処置をするための組成物および方法
Document Type and Number:
Japanese Patent JP5335191
Kind Code:
B2
Abstract:
Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Tip-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Tip-p8 expression.
Inventors:
Natarajan, Satish K.
Moreno, Offia
Gladys, Thomas Jay.
Duncan, David
Louth, Rainer
Chen, Feng
Moreno, Offia
Gladys, Thomas Jay.
Duncan, David
Louth, Rainer
Chen, Feng
Application Number:
JP2006524040A
Publication Date:
November 06, 2013
Filing Date:
August 20, 2004
Export Citation:
Assignee:
Dendreon Corporation
International Classes:
A61K31/16; A61K31/164; A61K31/165; A61K31/166; A61K31/167; A61K31/341; A61K31/36; A61K31/365; A61K31/381; A61K31/40; A61K31/4035; A61K31/404; A61K31/4045; A61K31/415; A61K31/416; A61K31/4184; A61K31/423; A61K31/437; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4439; A61K31/451; A61K31/47; A61K31/4709; A61K31/472; A61K31/495; A61K31/496; A61K31/498; A61K31/4985; A61K31/506; A61K31/513; A61K31/517; A61K31/519; A61K31/5375; A61K31/5377; A61K31/54; A61K31/55; A61K45/00; A61K45/06; A61P1/04; A61P11/00; A61P13/08; A61P15/00; A61P35/00; A61P43/00; C07C311/20; C07C311/37; C07C323/40; C07C323/44; C07C333/06; C07D207/06; C07D207/09; C07D207/325; C07D209/08; C07D209/14; C07D209/20; C07D209/48; C07D213/40; C07D215/04; C07D215/08; C07D215/46; C07D217/06; C07D231/12; C07D231/14; C07D231/56; C07D235/18; C07D235/26; C07D239/42; C07D241/18; C07D241/44; C07D251/54; C07D263/34; C07D263/57; C07D279/12; C07D295/096; C07D295/135; C07D295/26; C07D307/52; C07D317/66; C07D333/34; C07D401/04; C07D405/12; C07D413/04; C07D413/12; C07D417/04; C07D471/04; C07D487/04; C07D493/08; C07D495/04; C07D513/04; G01N33/68; C07D207/32; C07D263/56
Domestic Patent References:
| JP2007530418A | ||||
| JP47016647A | ||||
| JP47016648A | ||||
| JP2001279227A | ||||
| JP2000247910A | ||||
| JP7506868A |
Foreign References:
| US6497859 | ||||
| WO1993025177A1 |
Other References:
Chemical Abstracts,(1985), Vol.102,abstract No.24839
Chemical Abstracts,(1981), Vol.95,abstract No.220155
Chemical Abstracts,(1971), Vol.75,abstract No.110429
Chemical Abstracts,(1981), Vol.95,abstract No.220155
Chemical Abstracts,(1971), Vol.75,abstract No.110429
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita