Title:
高増殖性障害を処置する組成物および方法
Document Type and Number:
Japanese Patent JP2013510878
Kind Code:
A
Abstract:
A method of treating a hyperproliferative disorder in a subject in need of such treatment, comprising administering to said subject, in combination, a treatment effective amount of: (a) a ceramide-increasing retinoid such as fenretinide or a pharmaceutically acceptable salt thereof; and (b) at least one (and in certain embodiments at least two) compounds selected from the groups consisting of (i) a non-18 carbon chain length L-threo-sphinganine(s) or pharmaceuticeutically acceptable salt thereof, (ii) glucosylceramide or glucosyl(dihydro)ceramide synthesis inhibitor(s), and (iii) sphingomyelin or dihydrosphingomyelin synthase inhibitor(s). Preferred L-threo-sphinganines are of carbon chain length 17 carbons, 19 carbons and 20 carbons. A preferred glucosylceramide or glucosyl(dihydro)ceramide synthesis inhibitor is D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol.; A preferred sphingomyelin or dihydrosphingomyelin synthesis inhibitor is D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol. A preferred hyperproliferative disorder is brain cancers.
Inventors:
Barry James, Maurer
Reynolds, Charles Patrick
Reynolds, Charles Patrick
Application Number:
JP2012539046A
Publication Date:
March 28, 2013
Filing Date:
November 12, 2010
Export Citation:
Assignee:
Texas Tech University
International Classes:
C07C215/10; A61K31/133; A61K31/167; A61K31/5375; A61P25/00; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Hiroyuki Tomita
Osamu Hoshino
Hiroko Ejiri
Yasushi Kobayashi
Hiroyuki Tomita
Osamu Hoshino
Hiroko Ejiri