Title:
脱灰骨基質及び/又は石灰化骨基質と共に骨髄細胞を含む組成物並びに骨髄移植におけるその使用
Document Type and Number:
Japanese Patent JP2004525909
Kind Code:
A
Abstract:
A composition comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) and/or mineralized bone matrix (MBM), optionally comprising bone morphogenetic protein (BMP), particularly for use in bone marrow transplantation, into bone marrow cavity or into extraskeletal sites, and methods of transplantation/implantation thereof. The composition and methods of the invention enable restoring and/or enhancing the formation of hematopoiectic microenvironment originating from the transplanted BMC, and are useful in the treatment of hematopoietic disorders, such as deficiency of stem cells and/or their products, genetic conditions resulting in abnormal stem cells and/or products, or hematopoietic disorders of malignant or non-malignant origin. The composition and method of the invention may also be used for the induction of graft tolerence, for the prevention of graft-v-host disease. It is mostly important that the compositions and methods of the invention may be applied for the treatment of diseases affecting primarily or secondarily the stromal microenvironment that supports and regulates hematopoiesis. Further provided is a kit for transplantation into a mammal of BMC in admixture with DBM and/or MBM.
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Inventors:
Slavin, Simon
Grevic, Olga
Curkari, Basan Gouda S
Prigogina, Tatiana
Grevic, Olga
Curkari, Basan Gouda S
Prigogina, Tatiana
Application Number:
JP2002569163A
Publication Date:
August 26, 2004
Filing Date:
March 05, 2002
Export Citation:
Assignee:
Slavin, Simon
International Classes:
A61K35/12; A61K35/28; A61K35/32; A61K38/18; A61P7/06; A61P19/02; A61P19/08; A61K38/22; A61P35/00; C12N5/08; (IPC1-7): A61K35/12; A61K35/28; A61K35/32; A61K38/22; A61P7/06; A61P19/08; A61P35/00
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda