Title:
COMPOSITIONS CONTAINING HC-HA/PTX3 COMPLEXES AND METHODS OF USE THEREOF
Document Type and Number:
Japanese Patent JP2019178144
Kind Code:
A
Abstract:
To provide: methods for production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of inter α inhibitor (IαI); and compositions containing the complexes and therapeutic methods using the complexes.SOLUTION: The invention provides use of reconstituted HC-HA/PTX3 complexes or isolated native HC-HA/PTX3 complexes in production of formulations to promote or induce tissue regeneration. In the use, the tissue is bone, gums, corneal tissue, skin, nerves, soft tissue or conjunctival tissue.SELECTED DRAWING: Figure 3
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Inventors:
TSENG SCHEFFER
HE HUA
TIGHE SEAN
ZHANG SUZHEN
ZHU YING-TIENG
HE HUA
TIGHE SEAN
ZHANG SUZHEN
ZHU YING-TIENG
Application Number:
JP2019103107A
Publication Date:
October 17, 2019
Filing Date:
May 31, 2019
Export Citation:
Assignee:
TISSUETECH INC
International Classes:
A61K31/728; A61K9/06; A61K9/08; A61K9/10; A61K9/12; A61K9/127; A61K9/14; A61K9/16; A61K9/20; A61K9/48; A61K31/737; A61K38/17; A61K38/39; A61K38/58; A61K47/64; A61P1/02; A61P17/00; A61P19/02; A61P19/04; A61P19/08; A61P25/00; A61P27/02; A61P43/00; C07K14/47; C07K14/75; C07K14/78; C12N9/99
Domestic Patent References:
| JP2009510091A | 2009-03-12 |
Other References:
HUA HE: "BIOCHEMICAL CHARACTERIZATION AND FUNCTION OF COMPLEXES FORMED BY HYALURONAN AND THE HEAVY CHAINS OF", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 30, JPN5015008283, 2 June 2009 (2009-06-02), pages 20136 - 20146, XP055085809, ISSN: 0004268673, DOI: 10.1074/jbc.M109.021881
Attorney, Agent or Firm:
Kazuhiro Kiyohara