局所的有効成分の増強された配合安定性および送達を示す組成物

Title:

局所的有効成分の増強された配合安定性および送達を示す組成物

Document Type and Number:

Japanese Patent JP4979109

Kind Code:

B2

Abstract:

The present invention concerns a process for the preparation of microcapsules having a core-shell structure, wherein said microcapsules have a diameter of approximately 0.1 to 100 micron, wherein each core includes at least one active ingredient, said core is encapsulated within a microcapsular shell, and wherein said shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and said microcapsular shell protects the active ingredient prior to topical application and releases said active ingredient after topical application, said process comprises the steps of; (a) preparing a hydrophobic solution or a hydrophobic dispersion comprising sol-gel precursors and an ingredient to be encapsulated; (b) emulsifying the hydrophobic solution or dispersion of step (a) in an aqueous solution under high shear forces to obtain an emulsion; (c) mixing and stirring the emulsion obtained, with a second aqueous solution, at a selected pH to obtain the sol-gel microcapsules.

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Inventors:

Lapidot, Noah
Magdash, Shlomo
Avenir, david
Rotman, Claudio
Guns, orrit
Seri-Levy, Aaron

Application Number:

JP2001577923A

Publication Date:

July 18, 2012

Filing Date:

April 20, 2001

Export Citation:

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Assignee:

Sol-Gel Technologies Limited

International Classes:

A61K9/50; A61K8/00; A61K8/02; A61K8/04; A61K8/06; A61K8/11; A61K8/25; A61K8/36; A61K8/37; A61K8/38; A61K8/40; A61K8/41; A61K8/42; A61K8/44; A61K8/46; A61K8/49; A61K8/60; A61K8/64; A61K8/67; A61K8/72; A61K8/73; A61K8/81; A61K8/89; A61K8/891; A61K9/06; A61K9/08; A61K9/10; A61K9/107; A61K31/07; A61K31/166; A61K31/19; A61K31/375; A61K31/7048; A61K31/7056; A61K33/10; A61K33/22; A61K45/00; A61K47/12; A61K47/14; A61K47/18; A61K47/30; A61K47/36; A61K47/42; A61P1/02; A61P3/02; A61P17/00; A61P17/02; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P43/00; A61Q5/00; A61Q5/02; A61Q5/12; A61Q11/00; A61Q17/04; A61Q19/00; B01J13/04; A61K9/51

Foreign References:

WO2000009652A1

Attorney, Agent or Firm:

Nobuaki Kazehaya
Noriko Asano

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