Title:
生分解性化合物、脂質粒子、脂質粒子を含む組成物、およびキット
Document Type and Number:
Japanese Patent JP6997862
Kind Code:
B2
Abstract:
The present embodiment provides a method for delivering activators to cells, wherein said activator containing lipid particles are brought into contact with the cells,where a compound represented by the formula (1): Q-CHR2 (1)whereinQ is represented by the following formula (1-Q): RQ12N-(CRQ22)q1-NRQ1-(CRQ22)q2-* (1-Q)whereineach RQ1 is independently an alkyl,each RQ2 is independently hydrogen or an alkyl,any two of RQ1s and RQ2s may link together to form a nitrogen-containing alicyclic ring,q1 is an integer of 1 to 4,q2 is an integer of 0 to 4, andthe mark * indicates the position bonding to -CHR2; andeach R is independently an aliphatic group of C12 to C24;wherein said R is represented by the following formula (1-R): -LR1-C(=O)-O-LR2 (1-R)whereLR1 is alkylene andLR2 is represented by the following formula (1-R2): -CH2-CH=CH-(CH2)r2-H (1-R2)where r2 is an integer of 1 to 10.
Inventors:
Ishihara Mitsuko
Eiichi Akahoshi
Katsuyuki Naito
Emi Nozaki
Saeko Saruwatari
Eiichi Akahoshi
Katsuyuki Naito
Emi Nozaki
Saeko Saruwatari
Application Number:
JP2020512056A
Publication Date:
February 10, 2022
Filing Date:
March 14, 2019
Export Citation:
Assignee:
Toshiba Corporation
International Classes:
C07C229/24; A61K9/127; A61K31/7088; A61K47/18; A61K47/22; A61K47/24; A61K47/28; A61K47/34; A61P43/00; C07D233/02; C07D243/08; C07D251/04; C07D295/13; C07D295/15
Domestic Patent References:
JP2018524330A |
Foreign References:
WO2017222016A1 |
Attorney, Agent or Firm:
Nakamura Yukitaka
Takeshi Sekine
Jun Suzuki
Maekawa Hideaki
Takeshi Sekine
Jun Suzuki
Maekawa Hideaki
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