Title:
COMPOSITIONS FOR MANIPULATING LIFESPAN AND STRESS RESPONSE OF CELLS AND ORGANISMS
Document Type and Number:
Japanese Patent JP2014159448
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide methods and compositions for modulating the activity of sirtuin deacetylase protein family members; apoptosis; and lifespan and sensitivity to stress of cells and organisms.SOLUTION: A method comprises contacting a cell with: a sirtuin deacetylase protein family member activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or a sirtuin deacetylase protein family member inhibitory compound, such as a sphingolipid, e.g., sphingosine.
Inventors:
SINCLAIR DAVID A
HOWITZ KONRAD T
ZIPKIN ROBERT E
HOWITZ KONRAD T
ZIPKIN ROBERT E
Application Number:
JP2014081362A
Publication Date:
September 04, 2014
Filing Date:
April 10, 2014
Export Citation:
Assignee:
HARVARD COLLEGE
BIOMOL INTERNATL LP
BIOMOL INTERNATL LP
International Classes:
A61K31/05; A61K31/00; A61K31/121; A61K31/133; A61K31/175; A61K31/185; A61K31/352; A61K31/353; A61K36/87; A61K45/06; A61P9/00; A61P9/12; A61P17/00; A61P19/02; A61P25/28; A61P35/00; A61P43/00; C12N9/16
Domestic Patent References:
| JP2001048722A | 2001-02-20 |
Other References:
JPN6014031020; Ｊｏｕｒｎａｌ ｏｆ Ｍｏｌｅｃｕｌａｒ Ｃａｔａｌｙｓｉｓ Ｂ： Ｅｎｚｙｍａｔｉｃ １６, 2001, ２２３-９
JPN5006008856; ＲＥＳＥＡＲＣＨ ＣＯＭＭＵＮＩＣＡＴＩＯＮＳ ＩＮ ＰＨＡＲＭＡＣＯＬＯＧＹ ＡＮＤ ＴＯＸＩＣＯＬＯＧＹ， ＰＪＤ ＰＵＢＬＩＣＡＴＩＯＮＳ Ｖ５ Ｎ１／２, 2000, Ｐ１０７-１２１
JPN7010001762; ＥＭＢＯ Ｊ Ｖｏｌ．２１， Ｎｏ．１０, 2002, ｐ．２３８３-９６
JPN5006008856; ＲＥＳＥＡＲＣＨ ＣＯＭＭＵＮＩＣＡＴＩＯＮＳ ＩＮ ＰＨＡＲＭＡＣＯＬＯＧＹ ＡＮＤ ＴＯＸＩＣＯＬＯＧＹ， ＰＪＤ ＰＵＢＬＩＣＡＴＩＯＮＳ Ｖ５ Ｎ１／２, 2000, Ｐ１０７-１２１
JPN7010001762; ＥＭＢＯ Ｊ Ｖｏｌ．２１， Ｎｏ．１０, 2002, ｐ．２３８３-９６
Attorney, Agent or Firm:
Masahiro Mizuno