Title:
経口可溶性投与剤形のための組成物および製造方法
Document Type and Number:
Japanese Patent JP2004520410
Kind Code:
A
Abstract:
Compositions and methods of manufacture for dissolvable and nondissolvable drug-containing dosage-forms for noninvasive administration of medicaments through mucosal tissues of the mouth, pharynx, and esophagus of a patient. The dosage-forms are particularly useful in the transmucosal delivery of central nervous system affecting drugs in a dose-to-effect manner such that a sufficient dose is administered to produce a desired effect. A dissolvable drug-containing dosage-form includes a binding agent that is formed into a solid matrix dissolvable in the mouth of the patient, and a pharmacologically effective dose of a central nervous system affecting drug dispersed throughout the matrix. A nondissolvable drug-containing dosage-form includes a drug containment matrix that is nondissolvable in the mouth of the patient, and a central nervous system affecting drug incorporated into the nondissolvable matrix. The dissolvable and nondissolvable drug-containing dosage-forms may include permeation enhancers capable of modifying the permeability of the mucosal tissues of the mouth, pharynx, and esophagus in order to facilitate transmucosal absorption of the drug.
More Like This:
Inventors:
Coleman, Dennis El
Application Number:
JP2002567271A
Publication Date:
July 08, 2004
Filing Date:
February 27, 2002
Export Citation:
Assignee:
Cefalon Incorporated
International Classes:
A61K9/20; A61K9/00; A61K9/50; A61K31/452; A61K31/515; A61K31/5517; A61K47/02; A61K47/12; A61K47/14; A61K47/26; A61K47/28; A61K47/36; A61K47/38; A61K47/42; A61K47/44; A61P23/00; A61P25/04; A61P25/22; A61P29/00; (IPC1-7): A61K9/20; A61K9/50; A61K31/452; A61K31/515; A61K31/5517; A61K47/02; A61K47/12; A61K47/14; A61K47/26; A61K47/28; A61K47/36; A61K47/38; A61K47/42; A61K47/44; A61P23/00; A61P25/04; A61P25/22; A61P29/00
Attorney, Agent or Firm:
Heikichi Odashima