Title:
COMPOSITIONS AND METHOD FOR TREATING COMPLEMENT-ASSOCIATED CONDITIONS
Document Type and Number:
Japanese Patent JP2020028293
Kind Code:
A
Abstract:
To provide methods for selecting and identifying a patient for treating with a factor D inhibitor.SOLUTION: Provided is a method of predicting progression rate of a degenerative disease in a patient having the degenerative disease, the method comprising: (a) determining the presence of at least one degenerative disease-associated polymorphism in a biological sample obtained from the patient by (i) providing a nucleic acid sample isolated from the biological sample, and (ii) detecting the genotype of the nucleic acid sample for the presence of at least one degenerative disease-associated polymorphism, the polymorphism being a risk allele selected from the group consisting of a CFI allele, a CFH allele, a C2 allele, a CFB allele, or a C3 allele; and (b) identifying the patient as more likely to have increased rate of progression of the degenerative disease, when at least one risk allele selected from the group consisting of a CFI allele, a CFH allele, a C2 allele, a CFB allele, or a C3 allele is present.SELECTED DRAWING: Figure 7
Inventors:
BRIAN YASPAN
ROBERT ROYAL GRAHAM
AMY DRESSEN
LI ZHENGRONG
ERICH STRAUSS
TEODORICA BUGAWAN
ROBERT ROYAL GRAHAM
AMY DRESSEN
LI ZHENGRONG
ERICH STRAUSS
TEODORICA BUGAWAN
Application Number:
JP2019154149A
Publication Date:
February 27, 2020
Filing Date:
July 30, 2019
Export Citation:
Assignee:
GENENTECH INC
International Classes:
C12Q1/6883; A61K39/395; A61P27/02; C12Q1/6827; C12Q1/683; C12Q1/686; C12Q1/6869; G01N33/50; G01N33/53
Domestic Patent References:
| JP6463359B2 | 2019-01-30 | |||
| JP2010526074A | 2010-07-29 | |||
| JP2010508819A | 2010-03-25 | |||
| JP2011521623A | 2011-07-28 |
Other References:
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2012, VOL.53, P.1548-1556, JPN6017010549, ISSN: 0004336102
OPHTHALMOLOGY, 2011, VOL.118, P.2203-2211, JPN6017010552, ISSN: 0004336103
J MED GENET, 2009, VOL.46, P.300-307, JPN6017010554, ISSN: 0004336104
NATURE GENETICS, APRIL 2013, VOL.45, P.433-441, JPN6017010556, ISSN: 0004336105
PLOS ONE, 2011, VOL.6, E25598, JPN6017010559, ISSN: 0004336106
OPHTHALMOLOGY, 2011, VOL.118, P.2203-2211, JPN6017010552, ISSN: 0004336103
J MED GENET, 2009, VOL.46, P.300-307, JPN6017010554, ISSN: 0004336104
NATURE GENETICS, APRIL 2013, VOL.45, P.433-441, JPN6017010556, ISSN: 0004336105
PLOS ONE, 2011, VOL.6, E25598, JPN6017010559, ISSN: 0004336106
Attorney, Agent or Firm:
Sonoda/Kobayashi Patent Business Corporation