Title:
抗ＬＹＳＴによる免疫調整のための組成物及び方法
Document Type and Number:
Japanese Patent JP7343305
Kind Code:
B2
Abstract:
Excessive or repeated activation of inflammatory and pro-coagulant mechanisms at the site of tissue injury contributes to the development scar tissue that can lead to intimal hyperplasia and fibrotic disease. It has been established that inhibition of the LYST protein is associated with reduced inflammatory responses and reduced platelet activation at the site of tissue damage. Compositions and methods for inhibition of the expression and function of the LYST protein are described. The compositions and methods can be useful for the modulation of immune processes that contribute to formation of neointima and fibroproliferative disorders by altering macrophage, platelet and natural killer cell function to create a pro-regenerative immune response.
Inventors:
Christopher Brewer
Shigetoshi Hibino
Vidhu Garg
cameron best
Shigetoshi Hibino
Vidhu Garg
cameron best
Application Number:
JP2019098654A
Publication Date:
September 12, 2023
Filing Date:
May 27, 2019
Export Citation:
Assignee:
Research Institute at Nation Wide Children's Hospital
International Classes:
A61K39/395; A61K9/107; A61K9/127; A61K9/16; A61K9/51; A61K31/7088; A61K31/7105; A61K31/713; A61K48/00; A61L27/54; A61L29/16; A61L31/16; A61P9/00; A61P17/02; A61P37/06; A61P43/00
Domestic Patent References:
| JP2002510490A | ||||
| JP2002514897A |
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto