Title:
インビボでRNA干渉を媒介するための組成物および方法
Document Type and Number:
Japanese Patent JP2011517676
Kind Code:
A
Abstract:
The invention describes a method for muscle-specific delivery of oligonucleotides to induce gene silencing by RNA interference or silencing of microRNAs in vivo. A liposome comprising triacylglycerol, phospholipids, glycerol and lipid-binding proteins aggregated via a linker molecule with a single- or double-stranded oligonucleotide that is stabilized by one or more oligonucleotide modifications is isolated from Intralipid and serves as tissue-specific carrier.
Inventors:
Akin Akink
Tomoko Nakayama
David Connies
Marx Stoffel
Christian Wolfrum
Tomoko Nakayama
David Connies
Marx Stoffel
Christian Wolfrum
Application Number:
JP2011502065A
Publication Date:
June 16, 2011
Filing Date:
March 26, 2009
Export Citation:
Assignee:
ALNYLAM PHARMACEUTICALS, INC.
ETH ZUERICH
ETH ZUERICH
International Classes:
A61K31/7088; A61K9/107; A61K9/127; A61K31/7105; A61K31/7115; A61K31/7125; A61K31/713; A61K47/10; A61K47/14; A61K47/24; A61K47/28; A61K47/44; A61K47/48; A61K48/00; C12N15/09
Foreign References:
| WO2008004058A2 | 2008-01-10 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Mina Shiga
Masayuki Nakagawa
Fumio Inai
Manami Sawamoto
Hiroshi Yamazaki
Kenji Tomita
Mina Shiga
Masayuki Nakagawa
Fumio Inai
Manami Sawamoto