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Patent Searching and Data


Title:
COMPOSITIONS AND METHODS FOR MODIFYING REGULATORY T CELLS
Document Type and Number:
Japanese Patent JP2023182637
Kind Code:
A
Abstract:
To provide a method of stabilizing regulatory T cells, and a method of actively destabilizing regulatory T cells to remove tolerogenic effects in a tumor microenvironment.SOLUTION: Provided herein are compositions and methods for modifying regulatory T cells. The inventors have identified nuclear factors that influence expression of Foxp3, a key transcriptional regulator of Treg cells. Treg cells can be modified by inhibiting and/or overexpressing one or more of these nuclear factors to produce stabilized Treg cells or destabilized Treg cells.SELECTED DRAWING: Figure 1

Inventors:
ALEXANDER MARSON
JESSICA T CORTEZ
JEFFREY A BLUESTONE
ERIC SHIFRUT
FREDERIC VAN GOOL
Application Number:
JP2023158419A
Publication Date:
December 26, 2023
Filing Date:
September 22, 2023
Export Citation:
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Assignee:
UNIV CALIFORNIA
International Classes:
C12N5/0783; A61K35/17; A61P35/00; A61P37/06; A61P43/00; C12N5/10; C12N15/09; C12N15/113
Attorney, Agent or Firm:
Hatsushi Shimizu
Hideki Kodera
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto