Title:
COMPOSITIONS AND METHODS FOR MODIFYING REGULATORY T CELLS
Document Type and Number:
Japanese Patent JP2023182637
Kind Code:
A
Abstract:
To provide a method of stabilizing regulatory T cells, and a method of actively destabilizing regulatory T cells to remove tolerogenic effects in a tumor microenvironment.SOLUTION: Provided herein are compositions and methods for modifying regulatory T cells. The inventors have identified nuclear factors that influence expression of Foxp3, a key transcriptional regulator of Treg cells. Treg cells can be modified by inhibiting and/or overexpressing one or more of these nuclear factors to produce stabilized Treg cells or destabilized Treg cells.SELECTED DRAWING: Figure 1
Inventors:
ALEXANDER MARSON
JESSICA T CORTEZ
JEFFREY A BLUESTONE
ERIC SHIFRUT
FREDERIC VAN GOOL
JESSICA T CORTEZ
JEFFREY A BLUESTONE
ERIC SHIFRUT
FREDERIC VAN GOOL
Application Number:
JP2023158419A
Publication Date:
December 26, 2023
Filing Date:
September 22, 2023
Export Citation:
Assignee:
UNIV CALIFORNIA
International Classes:
C12N5/0783; A61K35/17; A61P35/00; A61P37/06; A61P43/00; C12N5/10; C12N15/09; C12N15/113
Attorney, Agent or Firm:
Hatsushi Shimizu
Hideki Kodera
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto
Hideki Kodera
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto