Title:
変異体クロストリジウム・ディフィシル毒素に関する組成物およびその方法
Document Type and Number:
Japanese Patent JP6892425
Kind Code:
B2
Abstract:
In one aspect, the invention relates to an immunogenic composition that includes a mutanttoxin A and/or a mutanttoxin B. Each mutant toxin includes a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type.toxin. The mutant toxins may further include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to antibodies or binding fragments thereof that binds to said immunogenic compositions. In further aspects, the invention relates to isolated nucleotide sequences that encode any of the foregoing, and methods of use of any of the foregoing compositions.
Inventors:
Anderson, Anally The Civil
Donald, Robert G. Kay
Flint, Michael James
Jansen, Katrin Ute
Kalyan, Naren Kay
Minnie, Teri El
Moran, Justin Keith
Ruppen, Mark Yi
Sidu, Maninder Kay
Donald, Robert G. Kay
Flint, Michael James
Jansen, Katrin Ute
Kalyan, Naren Kay
Minnie, Teri El
Moran, Justin Keith
Ruppen, Mark Yi
Sidu, Maninder Kay
Application Number:
JP2018192593A
Publication Date:
June 23, 2021
Filing Date:
October 11, 2018
Export Citation:
Assignee:
Weiss LRC
International Classes:
A61K39/08; A61K39/39; A61K47/08; A61K47/18; A61K47/24; A61K47/26; A61P31/04
Foreign References:
| WO2010063693A1 |
Other References:
Microbiology,2001年,Vol.147,p.439-447
Infect Immun,2007年,Vol.75, No.6,p.2826-2832
Infect Immun,2007年,Vol.75, No.6,p.2826-2832
Attorney, Agent or Firm:
Noh four
Junko Miyazawa
Maki Sato
Tatsuta Miyuki
Rie Ikeda
Junko Miyazawa
Maki Sato
Tatsuta Miyuki
Rie Ikeda