Title:
COMPOSITIONS AND METHODS FOR PERSONALIZED NEOPLASIA VACCINES
Document Type and Number:
Japanese Patent JP2022105069
Kind Code:
A
Abstract:
To provide methods of making a personalized neoplasia vaccine for a subject diagnosed as having a neoplasia.SOLUTION: The method comprises: identifying a plurality of mutations in a neoplasia; analyzing the plurality of mutations to identify a subset of at least five neo-antigenic mutations predicted to encode neo-antigenic peptides, the neo-antigenic mutations being selected from the group consisting of missense mutations, neoORF mutations, and any combination thereof; and producing, based on the identified subset, a personalized neoplasia vaccine.SELECTED DRAWING: Figure 1
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Inventors:
NIR HACOHEN
CATHERINE J WU
EDWARD F FRITSCH
CATHERINE J WU
EDWARD F FRITSCH
Application Number:
JP2022070352A
Publication Date:
July 12, 2022
Filing Date:
April 21, 2022
Export Citation:
Assignee:
BROAD INST INC THE
DANA FARBER CANCER INST INC
MASSACHUSETTS GEN HOSPITAL
DANA FARBER CANCER INST INC
MASSACHUSETTS GEN HOSPITAL
International Classes:
C12Q1/68; A61K39/00; A61P35/00; A61P37/04; C07K7/06; C12Q1/6827; C12Q1/6869; G01N33/50; G01N33/68
Domestic Patent References:
| JP2016518355A | 2016-06-23 | |||
| JP2012522500A | 2012-09-27 |
Foreign References:
| WO2011143656A2 | 2011-11-17 | |||
| WO2012159754A2 | 2012-11-29 | |||
| WO2008096831A1 | 2008-08-14 |
Other References:
CLIN. CANCER. RES., vol. Vol.18(23), JPN6018001239, 2012, pages 6497 - 6508, ISSN: 0005099606
Attorney, Agent or Firm:
Osamu Yamamoto
Toru Miyamae
Takuji Terachi
Toru Miyamae
Takuji Terachi