Title:
COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF CANCER
Document Type and Number:
Japanese Patent JP2017014255
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide compositions and methods related to immunotherapy and medicine which expand tumor-specific T cells that can efficiently attack cancerous cells.SOLUTION: The invention provides a method of treating a tumor or cancer in a subject comprising administering to the subject a conjugate, consisting of nanoparticles coated with a tumor specific antigen-presenting MHC class I and/or class II molecule and a costimulatory molecule, in an amount sufficient to expand a population of antigen-specific anti-tumorigenic T cells specific to the tumor or cancer. The antigen-specific anti-tumorigenic T cells include cytotoxic T cells, effector T cells, memory T cells, and helper T cells, which are necessary to initiate and maintain a substantial immune response against metastatic or non-metastatic cancerous, pre-cancerous, or neoplastic cells in vivo. The method comprises a systemic approach targeting cancerous or pre-cancerous cells that are circulating cells in lymphomas and the like, migratory metastatic cells, and solid tumors.SELECTED DRAWING: Figure 2
Inventors:
PERE SANTAMARIA
Application Number:
JP2016159414A
Publication Date:
January 19, 2017
Filing Date:
August 16, 2016
Export Citation:
Assignee:
UTI LIMITED PARTNERSHIP
International Classes:
A61K39/385; A61K9/14; A61K39/00; A61K47/02; A61K47/50; A61P35/00; A61P35/04; A61P43/00
Domestic Patent References:
| JP5991979B2 | 2016-09-14 | |||
| JP2010522695A | 2010-07-08 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto