Title:
COMPOSITIONS AND METHODS FOR THERAPEUTIC USE OF ATONAL-ASSOCIATED SEQUENCE FOR HEARING DISORDER, OSTEOARTHRITIS, AND ABNORMAL CELL PROLIFERATION
Document Type and Number:
Japanese Patent JP2014147387
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide characterization and use of an atonal-associated nucleic acid or amino acid sequence, or any of its homologs or orthologs, as a therapeutic agent for the treatment of deafness, partial hearing loss, vestibular deafness due to damage or loss of inner ear hair cells, osteoarthritis, and abnormal cell proliferation.SOLUTION: Compositions and methods are disclosed for the therapeutic use of an atonal-associated nucleic acid or amino acid sequence. In addition, an animal heterozygous for an atonal-associated gene inactivation is also disclosed having at least one atonal-associated nucleic acid sequence replaced by insertion of a heterologous nucleic acid sequence used to detect expression driven by an atonal-associated promoter sequence, where the inactivation of the atonal-associated nucleic acid sequence prevents expression of the atonal-associated gene.
Inventors:
ZOGHBI HUDA Y
BELLEN HUGO
BIRMINGHAM NESSAN
HASSAN BASSEM
BEN-ARIE NISSIM
BELLEN HUGO
BIRMINGHAM NESSAN
HASSAN BASSEM
BEN-ARIE NISSIM
Application Number:
JP2014048148A
Publication Date:
August 21, 2014
Filing Date:
March 11, 2014
Export Citation:
Assignee:
BAYLOR COLLEGE MEDICINE
International Classes:
A01K67/027; A01K67/033; A61K9/08; A61K9/127; A61K9/14; A61K9/20; A61K9/46; A61K9/48; A61K47/26; A61K47/42; A61K47/44; A61K48/00; A61P19/02; A61P25/00; A61P27/16; A61P35/00; A61P43/00; C07K14/46; C07K14/465; C07K14/47; C07K14/705; C12N5/08; C12N5/10; C12N15/09; C12N15/12; C12Q1/68; G01N33/15; G01N33/50; A61K38/00
Other References:
JPN6015024013; Ｄｅｖｅｌｏｐｍｅｎｔａｌ Ｂｉｏｌｏｇｙ Ｖｏｌ． １８７， Ｎｏ． １, 1997, ｐ． １-１２
Attorney, Agent or Firm:
Patent business corporation ユニアス international patent firm