Title:
補体媒介性疾患を処置するための組成物及び方法
Document Type and Number:
Japanese Patent JP7324253
Kind Code:
B2
Abstract:
A recombinant vector having an expression cassette comprising a modified human factor H (hfH) gene is provided, wherein said hfH gene encodes a hfH protein variant comprising SCR1-4, 19-20, and one or more of SCR7, SCR17 and/or SCR18. Also provided are pharmaceutical compositions containing this vector and uses therefor in treating AMD and/or other complement associated diseases.
Inventors:
Song Song Super
Garipari, Damodal
Takashi Miwa
Garipari, Damodal
Takashi Miwa
Application Number:
JP2021128847A
Publication Date:
August 09, 2023
Filing Date:
August 05, 2021
Export Citation:
Assignee:
The Trustees of the University of Pennsylvania
International Classes:
C12N15/86; A61K9/127; A61K35/76; A61K35/761; A61K38/17; A61K47/60; A61K48/00; A61P7/04; A61P7/06; A61P9/10; A61P13/12; A61P25/18; A61P27/02; A61P31/04; A61P43/00; C07K14/47; C12N15/12; C12N15/861; C12N15/863; C12N15/864; C12N15/867
Domestic Patent References:
| JP2018527941A | ||||
| JP2013515474A |
Foreign References:
| WO2015092335A2 | ||||
| US20150110766 |
Other References:
Drug Discovery System (2007) Vol.22-6, pp.643-650
坂田洋一,血友病遺伝子治療の最新情報と展望,Hemophilia Topics (2007) Vol.13, pp.1-4, バイエル薬品株式会社 [online], [検索日 2020.7.14],
坂田洋一,血友病遺伝子治療の最新情報と展望,Hemophilia Topics (2007) Vol.13, pp.1-4, バイエル薬品株式会社 [online], [検索日 2020.7.14],
Attorney, Agent or Firm:
Patent Attorney Corporation Odashima Patent Office
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