Title:
内分泌型ＦＧＦ関連疾患を処置または防止するための組成物および方法
Document Type and Number:
Japanese Patent JP7316946
Kind Code:
B2
Abstract:
The present invention relates in one aspect to the discovery that β-Klotho is the primary cell-surface receptor for FGF21, with FGFR1c functioning as a catalytic subunit that ultimately mediates intracellular signaling. In one aspect, the invention provides compositions and methods that are useful in treating or preventing endocrine FGF-related diseases or disorders.
Inventors:
Schlesinger Joseph
Lee Sang Won
Lee Sang Won
Application Number:
JP2019572539A
Publication Date:
July 28, 2023
Filing Date:
July 05, 2018
Export Citation:
Assignee:
Yale University
International Classes:
C12N15/62; A61K39/395; A61K45/00; A61K45/06; A61P1/04; A61P1/16; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P35/00; A61P43/00; C07K14/50; C07K16/24; C07K19/00
Domestic Patent References:
| JP2013512689A | ||||
| JP2011523561A | ||||
| JP2017509628A | ||||
| JP2014527402A |
Foreign References:
| US20130231277 | ||||
| US20130331316 | ||||
| WO2017079768A1 |
Other References:
Zoller, M J, and M Smith,Nucleic Acids Research,Vol. 10, No. 20,1982年,p. 6487-6500
Regina Goetz et al.,Molecular and Cellular Biology,2012年05月,Vol. 32, No. 10,p. 1944-1954
Richard Smith et al.,PLOS ONE,2013年04月,Vol. 8, Issue 4, e61432,p. 1-11
Ganesh Kolumam et al.,EBioMedicine,2015年05月30日,Vol. 2,p. 730-743
Regina Goetz et al.,Molecular and Cellular Biology,2012年05月,Vol. 32, No. 10,p. 1944-1954
Richard Smith et al.,PLOS ONE,2013年04月,Vol. 8, Issue 4, e61432,p. 1-11
Ganesh Kolumam et al.,EBioMedicine,2015年05月30日,Vol. 2,p. 730-743
Attorney, Agent or Firm:
Hatsushi Shimizu
Hideki Kodera
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto
Hideki Kodera
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto
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