Title:
除去的放射線治療に使用される組成物およびその使用方法
Document Type and Number:
Japanese Patent JP2014511396
Kind Code:
A
Abstract:
Provided herein is the compound RK-33, or a salt, solvate, stereoisomer, or derivative thereof, which is shown to be an inhibitor if the DEAD box helicase DDX3, in mammalian cells. RK-33 is also provided herein for use as a radiation dose sensitizer in a subject suffering from a proliferative disease and undergoing radiation therapy. Methods of treatment of proliferative diseases, such as cancer with a combination of RK-33 and radiotherapy methods such as stereotactic ablative radiotherapy (SABR) are also provided.
Inventors:
Venue Raman
Puok Trang
Puok Trang
Application Number:
JP2013557897A
Publication Date:
May 15, 2014
Filing Date:
March 09, 2012
Export Citation:
Assignee:
The Johns Hopkins University
International Classes:
A61K31/551; A61K41/00; A61N5/10; A61P35/00; A61P43/00
Foreign References:
| WO2010003918A1 | 2010-01-14 |
Other References:
RAMAN, VENU ET AL.: "RNA Helicases: The Next Generation of Targets for Cancer Treatment", 2010 MIPS MOLECULAR IMAGING SEMINAR SERIES [オンライン], vol. [検索日 2015.12.10], JPN7015003579, 13 September 2010 (2010-09-13)
KONDASKAR, ATUL ET AL.: "Novel, Broad Spectrum Anticancer Agents Containingthe Tricyclic 5:7:5-Fused Diimidazodiazepine Ring", ACS MEDICINAL CHEMISTRY LETTERS, vol. 2, no. 3, JPN6015051235, 2011, pages 252 - 256, XP055122146, DOI: doi:10.1021/ml100281b
三橋紀夫: "化学放射線治療", 最新医学, vol. 64, no. 6, JPN6015051231, 10 June 2009 (2009-06-10), pages 27 - 34
古平毅: "化学療法と放射線治療の併用", 臨床放射線、頭頸部の診断と治療のＵＰＤＡＴＥ, vol. 53, no. 11, JPN6015051233, 2008, pages 1570 - 1577
橘昌幸ほか: "肺定位放射線治療におけるPencil Beam Convolution法およびAnisotropic Analytical Algorithm法による線量", 日本放射線技術学会雑誌, vol. 65, no. 7, JPN6016033797, 2009, pages 938 - 944
KAMIDA, TOHRU ET AL.: "Stereotactic Radiosurgery for Recurrent Pleomorphic Adenoma Invading the Skull Base", NEUROLOGIA MEDICO-CHIRURGICA, vol. 45, no. 3, JPN6017016175, 2005, pages 161 - 163
梶原浩司ほか: "下垂体腺腫に対するCyberKnifeによる定位放射線治療の効果", 日本内分泌学会雑誌, vol. Vol.79, Suppl., JPN6017016176, 2003, pages 139 - 140
KONDASKAR, ATUL ET AL.: "Novel, Broad Spectrum Anticancer Agents Containingthe Tricyclic 5:7:5-Fused Diimidazodiazepine Ring", ACS MEDICINAL CHEMISTRY LETTERS, vol. 2, no. 3, JPN6015051235, 2011, pages 252 - 256, XP055122146, DOI: doi:10.1021/ml100281b
三橋紀夫: "化学放射線治療", 最新医学, vol. 64, no. 6, JPN6015051231, 10 June 2009 (2009-06-10), pages 27 - 34
古平毅: "化学療法と放射線治療の併用", 臨床放射線、頭頸部の診断と治療のＵＰＤＡＴＥ, vol. 53, no. 11, JPN6015051233, 2008, pages 1570 - 1577
橘昌幸ほか: "肺定位放射線治療におけるPencil Beam Convolution法およびAnisotropic Analytical Algorithm法による線量", 日本放射線技術学会雑誌, vol. 65, no. 7, JPN6016033797, 2009, pages 938 - 944
KAMIDA, TOHRU ET AL.: "Stereotactic Radiosurgery for Recurrent Pleomorphic Adenoma Invading the Skull Base", NEUROLOGIA MEDICO-CHIRURGICA, vol. 45, no. 3, JPN6017016175, 2005, pages 161 - 163
梶原浩司ほか: "下垂体腺腫に対するCyberKnifeによる定位放射線治療の効果", 日本内分泌学会雑誌, vol. Vol.79, Suppl., JPN6017016176, 2003, pages 139 - 140
Attorney, Agent or Firm:
Kenji Sugimura
Hiroshi Ikeda
Miyuki Kami
Hiroshi Ikeda
Miyuki Kami