Title:
ｍＰＧＥＳ−１阻害剤としての化合物
Document Type and Number:
Japanese Patent JP2021504307
Kind Code:
A
Abstract:
本発明は、増強されたｍＰＧＥＳ−１発現又は活性により媒介された症状を予防又は抑制するための治療に使用される、２−ヒドロキシ−２−メチル−４−（３，５，６−トリメチル−１，４−ベンゾキノン−２−イル）−ブタン酸のアミド誘導体に関する。特に、本発明は、炎症性疾患、侵害受容性疼痛、自己免疫性疾患、呼吸障害、発熱、がん、炎症関連食欲不振、アルツハイマー病及び心血管疾患など、酵素ｍＰＧＥＳ−１の活性及び／又は発現の阻害が有益である疾患及び状態を治療するための、これらの化合物の使用に関する。【選択図】 なし
Inventors:
Smetink, Johannes Albertus Maria
Beiras, Julian David
Beiras, Julian David
Application Number:
JP2020526121A
Publication Date:
February 15, 2021
Filing Date:
November 22, 2018
Export Citation:
Assignee:
KHONDRION IP B.V.
International Classes:
C07C235/78; A61K9/08; A61K9/20; A61K31/16; A61K31/165; A61K31/197; A61K31/439; A61K31/445; A61K31/4462; A61K31/495; A61K47/02; A61P1/00; A61P1/04; A61P3/10; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P21/00; A61P25/14; A61P25/16; A61P25/28; A61P27/16; A61P29/00; A61P31/04; A61P31/16; A61P35/00; A61P35/02; A61P37/06; A61P37/08; A61P43/00; C07D211/56; C07D295/185; C07D471/08
Domestic Patent References:
| JP2011503005A | 2011-01-27 | |||
| JP2015522067A | 2015-08-03 | |||
| JP2017524674A | 2017-08-31 | |||
| JP2016511743A | 2016-04-21 | |||
| JPH02250831A | 1990-10-08 | |||
| JP2021504305A | 2021-02-15 |
Foreign References:
| WO2017060432A1 | 2017-04-13 | |||
| WO2016188766A1 | 2016-12-01 |
Other References:
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BIOCHEMICAL PHARMACOLOGY, vol. 98(1), JPN6022044789, 2015, pages 1 - 15, ISSN: 0004904521
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PROSTAGLANDINS AND OTHER LIPID MEDIATORS, vol. 121(3), JPN6022044791, 2015, pages 42 - 45, ISSN: 0004904523
Attorney, Agent or Firm:
Ikeda adult
Junichiro Sakamaki
Masakazu Noda
Junichiro Sakamaki
Masakazu Noda