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Title:
COMPOUND CAPABLE OF INHIBITING DISEASE CAUSED BY OXIDATIVE DAMAGE
Document Type and Number:
Japanese Patent JPH0925263
Kind Code:
A
Abstract:

To obtain a spin trapping agent, capable of forming a stable conjugate with a free radical and useful for treating apoplexy, etc.

This compound is represented by formula I {X is represented by formula II [R is H or represented by the formula Z-CO (Z is a 1-5C alkyl, etc.), etc.; (n) is an integer of 1-5]; Y is tert-butyl group, etc., capable of carrying out the hydroxylation, etc., of one or more sites}, e.g. α-phenyl-t-butylnitrone(PBN). The compound is capable of considerably protecting a gerbil which is a model of apoplexy from damage to a brain caused by an injury of ischemia/ reperfusion. The induction level of c-fos in the cerebral cortex of the gerbil due to the ischemia/reperfusion is suppressed by pretreatment with the PBN.


Inventors:
Carney, John M.
Floyd, Robert A.
Application Number:
JP1996000179709
Publication Date:
January 28, 1997
Filing Date:
July 09, 1996
Export Citation:
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Assignee:
OKLAHOMA MEDICAL RES FOUND
UNIV KENTUCKY RES FOUND
International Classes:
A61K31/13; A61K31/00; A61K31/135; A61K31/15; A61K31/16; A61K31/165; A61K31/167; A61K31/215; A61K31/22; A61K31/222; A61K31/265; A61K31/325; A61K31/40; A61K31/44; A61K31/4409; A61K31/4418; A61K31/4425; A61P3/00; A61P3/10; A61P9/00; A61P9/10; A61P25/00; A61P25/02; A61P25/16; A61P25/28; A61P25/30; A61P29/00; A61P31/12; A61P39/06; A61P43/00; C07C251/32; C07C291/02; C07D207/46; C07D213/89; (IPC1-7): C07C291/02; A61K31/16; A61K31/165; A61K31/22; A61K31/265; A61K31/40; A61K31/44; C07D207/46; C07D213/89
Domestic Patent References:
JPS53116145A
Foreign References:
US3767818A
US3775122A
GB1109472A
DE273702C
Attorney, Agent or Firm:
山本 秀策