COMPOUND FOR ENHANCING ACTION OF RETINOID - Pharmaceutical Molecular Design Laboratory Co., Ltd.

Title:

COMPOUND FOR ENHANCING ACTION OF RETINOID

Document Type and Number:

Japanese Patent JP3865829

Kind Code:

B2

Abstract:

PROBLEM TO BE SOLVED: To obtain a new compound having action enhancing action of a retinoid such as retinoic acid and useful for a medicinal composition.
SOLUTION: This retinoid action enhancing compound is represented by formula I (R1 is H or 1-6C alkyl; R2 and R3 are each independently H, a 1-6C alkyl or a 5-00 or 6-membered cycloalkyl ring; R4 is H, a 1-6C alkyl, a 1-6C alkoxy, hydroxyl group, etc.; X is NR7, O, etc.; R7 is H, a 1-6C alkyl or an aryl-substituted 1-6C alkyl) or formula II (R5 is H, a 1-6C alkyl or an aryl- substituted 1-6C alkyl; R6 is H or a 1-6C alkyl), e.g. 4-[5H-2,3-(2,5-dimethyl-2,5- hexano)-5-methyldibenzo[b,e][1,4] diazepin-11-yl]benzoic acid 4-[1,3- dihydro-7,8-(2,5-dimethyl-2,5-hexano)-2-oxo-2H-1,4-benzodiazepin-5-yl]denzoic acid.

More Like This:

JP2003526603	INDUSTRIAL APPLICABILITY: Succinoylaminolactams as Aβ protein production inhibitors
JP3886805	Benzodiazepine derivative
WO/2006/051851	2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION

Inventors:

Koichi Shudo

Application Number:

JP24596596A

Publication Date:

January 10, 2007

Filing Date:

September 18, 1996

Export Citation:

Click for automatic bibliography generation Help

Assignee:

Pharmaceutical Molecular Design Laboratory Co., Ltd.

International Classes:

C07D243/12; C07D243/38; A61K31/55; A61K31/5513; A61K31/553; A61K31/554; A61P3/02; A61P29/00; A61P35/00; A61P35/02; A61P37/00; A61P37/08; A61P43/00; C07D223/16; C07D223/20; C07D267/14; C07D267/20; C07D281/10; C07D281/16; C07D401/04; (IPC1-7): C07D243/38; A61K31/55; A61K31/55; A61K31/55; A61K31/55; A61K31/55; A61K31/55; A61K31/55; A61K31/55; A61K31/55; C07D223/16; C07D223/20; C07D243/12; C07D267/14; C07D267/20; C07D281/10; C07D281/16; C07D401/04; //(C07D401/04; C07D213:79; C07D243:38)

Domestic Patent References:

JP6263702A
JP7118134A

Foreign References:

US3499027
US3329701

Other References:

THE JOURNAL OF Organic Chemistry, 1972, Vol.37, No.24, pp.3755-3770
JOURNAL OF MEDICINAL CHEMISTRY, 1994, Vol.37, No.10, pp.1508-1517
Chem. Pharm. Bull., 1995, Vol.43, No.10, pp.1827-1829
ACTA CHEMICA SCANDINAVICA, 1966, Vol.20, No.6, pp.1631-1644

Attorney, Agent or Firm:

Patent Service Corporation Patent Office Sykes
Masazumi Imamura
Toshio Shiozawa
Junji Kamata

Previous Patent: SEMICONDUCTOR MEMORY AND DEFECT TESTING METHOD THEREFOR

Next Patent: SURFACE FASTENER USING BUILDING CONSTRUCTION