Title:
COMPOUND FOR INHIBITING RETROVIRUS PROTEASE
Document Type and Number:
Japanese Patent JP3914065
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a new compound that inhibits retrovirus proteases, especially proteases of human immunodeficiency virus(HIV), a composition for treating retrovirus infection, especially for treating HIV infection, a production method of the compound, and a synthetic intermediate used in the method.
SOLUTION: A compound represented by formula (A) is provided [wherein, R1, R2, R3 and R6 are each H or a lower alkyl group; R4 and R4a are each a phenyl, thiazolyl, oxazolyl, isoxazolyl or isothiazolyl group; X and Y are each H or OH; Z is none or O]. For example, (2S, 3S, 5S)-5-(N-(N-((N-methyl- N-((2-cyclohexyl-4-thiazolyl)methyl)amino)carbonyl)valinyl)amino-2-(N-((5- thiazolyl)methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane is provided.
Inventors:
Dale Jay Kemp
Daniel D'Abrieu Novetsk
Hin Rune Siam
Chiang Suao
Thomas the ray sowyn
Daniel S. Reno
Anthony Earl Height
Arthur Jay Cooper
Daniel D'Abrieu Novetsk
Hin Rune Siam
Chiang Suao
Thomas the ray sowyn
Daniel S. Reno
Anthony Earl Height
Arthur Jay Cooper
Application Number:
JP2002054592A
Publication Date:
May 16, 2007
Filing Date:
December 16, 1993
Export Citation:
Assignee:
Abbot Laboratories
International Classes:
C07D263/32; C07D275/02; A61K31/395; A61K31/415; A61K31/4164; A61K31/42; A61K31/421; A61K31/422; A61K31/425; A61K31/426; A61K31/427; A61K31/535; A61K31/5375; A61K31/5377; A61K31/54; A61K45/06; A61P31/12; A61P31/18; A61P35/00; A61P35/02; A61P37/04; A61P43/00; C07C33/46; C07C43/164; C07C43/174; C07C43/205; C07C43/215; C07C43/23; C07C43/30; C07C43/315; C07C45/00; C07C45/29; C07C45/56; C07C45/62; C07C45/67; C07C45/74; C07C53/134; C07C69/34; C07C69/65; C07C69/732; C07C211/27; C07C215/18; C07C215/20; C07C215/28; C07C229/08; C07C229/26; C07C229/34; C07C233/36; C07C233/40; C07C235/10; C07C235/12; C07C235/34; C07C235/78; C07C237/10; C07C237/20; C07C237/22; C07C239/10; C07C239/18; C07C239/20; C07C247/10; C07C251/40; C07C271/20; C07C271/22; C07C271/34; C07C275/16; C07C275/24; C07C311/03; C07C311/13; C07C311/18; C07C317/10; C07C317/28; C07C317/44; C07C323/12; C07C323/25; C07C381/00; C07D213/26; C07D213/30; C07D213/34; C07D213/40; C07D213/54; C07D213/56; C07D213/61; C07D213/75; C07D233/54; C07D233/84; C07D235/14; C07D235/16; C07D239/26; C07D241/12; C07D261/06; C07D261/08; C07D263/24; C07D263/30; C07D263/48; C07D265/30; C07D277/22; C07D277/24; C07D277/28; C07D277/30; C07D277/32; C07D277/34; C07D277/36; C07D277/40; C07D277/42; C07D277/56; C07D295/13; C07D295/205; C07D295/215; C07D303/36; C07D307/42; C07D333/16; C07D401/12; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D521/00; C07F5/02; C07F5/04; C07K5/06; C07K5/065; A61K38/00; C07D235/10; C07D; (IPC1-7): C07D263/32; A61K31/422; A61K31/426; A61K31/427; A61P31/12; A61P31/18; A61P43/00; C07D277/28; C07D413/12; C07D417/12
Domestic Patent References:
| JP4308574A |
Attorney, Agent or Firm:
Yoshio Kawaguchi