Title:
COMPOUND, METHOD AND FORMULATION FOR ORAL DELIVERY OF GLUCAGON LIKE PEPTIDE (GLP)-1 COMPOUND OR MELANOCORTIN 4 RECEPTOR (MC4) AGONIST PEPTIDE
Document Type and Number:
Japanese Patent JP2011207886
Kind Code:
A
Abstract:
To provide a new compound, method and formulation which are useful for oral delivery of a GLP-1 compound or an MC4 agonist peptide.
There is provided a compound represented by formula I, (wherein R1 and R2 are each independently H, OH, cyano, C1-C6 alkyl, C1-C6 alkoxy, CF3, halo or NR4R4'; R3 is H, C1-C6 alkyl; R4 is H, COR6, SO2R7, or C1-C6alkyl; R4' is H or C1-C6 alkyl; R6 is H or C1-C6 alkyl; X is a 5 membered aromatic heterocycle that is optionally substituted with C1-C4 alkyl; wherein the heterocycle contains at least two or three heteroatoms selected from N, S and O wherein at least one heteroatom must be N and n is 2, 3, 4, 5, 6 or 7) or pharmaceutical salt thereof.
Inventors:
HERR ROBERT JASON
JUNGHEIM LOUIS NICKOLAUS
MCGILL JOHN MCNEILL III
THRASHER KENNETH JEFF
VALLURI MURALIKRISHNA
JUNGHEIM LOUIS NICKOLAUS
MCGILL JOHN MCNEILL III
THRASHER KENNETH JEFF
VALLURI MURALIKRISHNA
Application Number:
JP2011104435A
Publication Date:
October 20, 2011
Filing Date:
May 09, 2011
Export Citation:
Assignee:
EMISPHERE TECH INC
International Classes:
C07D263/32; A61K38/00; A61K47/22; C07D233/54; C07D249/06; C07D249/08; C07D261/08; C07D271/06; C07D277/24; C07D285/12; C07D409/04; C07D413/04; C07K14/605; C07K14/705
Domestic Patent References:
| JP2002536400A | 2002-10-29 | |||
| JP2001131090A | 2001-05-15 | |||
| JP2002536400A | 2002-10-29 | |||
| JP2001131090A | 2001-05-15 | |||
| JP4767850B2 | 2011-09-07 |
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Masahiro Nitta
Kure Hidenori
Samejima Mutsumi
Masahiro Nitta
Kure Hidenori
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