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Title:
COMPOUND AND METHOD FOR USING THE SAME
Document Type and Number:
Japanese Patent JP2010043112
Kind Code:
A
Abstract:

To provide a compound useful for treating such diseases as inflammations, cardiovascular disorders and atherosclerosis as liver X receptor (LXR)-mediated diseases or symptoms.

The compound is represented by formula (I) (wherein, X is bromo, carboxyl, hydroxyl or the like; R1 to R9 are each independently H, halo, 1-6C alkyl or the like; Z is CH or N; Y is -O- or the like; W1 to W3 are each H, methyl, phenyl or the like; Q is 2-chloro-3-(trifluoromethyl)phenyl or the like; p is 0-2; n is 3; m is 0 or 1; q is 1; and t is 0 or 1).


Inventors:
THOMPSON SCOTT K
FRAZEE JAMES S
KALLANDER LARA S
MA CHUN
MARINO JOSEPH P
NEEB MICHAEL J
BHAT AJITA
MCATEE JOHN JEFFREY
STAVENGER ROBERT A
Application Number:
JP2009235246A
Publication Date:
February 25, 2010
Filing Date:
October 09, 2009
Export Citation:
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Assignee:
GLAXOSMITHKLINE LLC
International Classes:
C07C217/18; A61K31/138; A61K31/165; A61K31/167; A61K31/17; A61K31/18; A61K31/192; A61K31/197; A61K31/215; A61K31/216; A61K31/235; A61K31/27; A61K31/341; A61K31/357; A61K31/36; A61K31/381; A61K31/40; A61K31/41; A61K31/415; A61K31/417; A61K31/4196; A61K31/44; A61K31/451; A61K31/4525; A61K31/495; A61K31/496; A61K31/505; A61K31/5375; A61K31/5377; A61K31/54; A61P3/06; A61P9/00; A61P9/10; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P29/00; A61P43/00; C07C217/20; C07C217/22; C07C217/36; C07C217/48; C07C217/84; C07C219/22; C07C229/14; C07C229/18; C07C229/34; C07C233/25; C07C233/60; C07C235/08; C07C239/08; C07C255/54; C07C271/28; C07C275/34; C07C291/02; C07C291/04; C07C309/73; C07C311/08; C07C311/09; C07C311/21; C07C311/29; C07C311/45; C07C323/32; C07D207/16; C07D207/333; C07D207/335; C07D211/14; C07D211/22; C07D211/34; C07D211/60; C07D211/62; C07D213/36; C07D213/38; C07D213/64; C07D213/74; C07D231/14; C07D233/54; C07D233/64; C07D239/42; C07D249/08; C07D257/04; C07D295/08; C07D295/096; C07D295/12; C07D295/125; C07D295/14; C07D295/185; C07D307/66; C07D307/68; C07D317/58; C07D317/68; C07D319/18; C07D333/20; C07D401/02
Domestic Patent References:
JP2010047582A2010-03-04
JP2004509161A2004-03-25
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita
Nishino Mitsuru
Mizuhara Masahiro