Title:
化合物
Document Type and Number:
Japanese Patent JP2019528286
Kind Code:
A
Abstract:
【課題】本発明は、シチシンの新規な類似物、中毒の治療等の、薬剤におけるそれらの使用方法、及びシチシンの類似物を調整するための合成方法の改良版を提供する。【解決手段】シチシンの新規な類似物、類似物の調合プロセス、類似物を含む医薬組成物、及び嗜癖障害を含む中枢神経系障害の予防又は治療におけるシチシンの新規な類似物の使用方法を開示する。本発明のシチシンの新規な類似物の化学構造を化学式Ｉに示す。【化１】【選択図】なし
Inventors:
Gallagher Timothy Charles
Lego campello hugo
Lego campello hugo
Application Number:
JP2019510286A
Publication Date:
October 10, 2019
Filing Date:
August 17, 2017
Export Citation:
Assignee:
The University of Bristol
International Classes:
C07D471/18; A61K31/439; A61P39/02; C07F5/02
Domestic Patent References:
| JP2000505809A | 2000-05-16 |
Foreign References:
| WO2007115092A2 | 2007-10-11 | |||
| WO2007100430A2 | 2007-09-07 |
Other References:
KOZIKOWSKI, AP ET AL.: "Chemical Medicine: Novel 10-Substituted Cytisine Derivatives with Increased Selectivity for α4β2 N", CHEMMEDCHEM, vol. 2, JPN5019007773, 2007, pages 1157 - 1161, XP055433158, ISSN: 0004548187, DOI: 10.1002/cmdc.200700073
DURKIN, P ET AL.: "Lactam Enolate-Pyridone Addition: Synthesis of 4-Halocytisines", SYNLETT, JPN6021026750, 2010, pages 2789 - 2791, XP055433164, ISSN: 0004548188, DOI: 10.1055/s-0030-1259006
DURKIN, P ET AL.: "Lactam Enolate-Pyridone Addition: Synthesis of 4-Halocytisines", SYNLETT, JPN6021026750, 2010, pages 2789 - 2791, XP055433164, ISSN: 0004548188, DOI: 10.1055/s-0030-1259006
Attorney, Agent or Firm:
Masaki Hattori