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Patent Searching and Data


Title:
化合物
Document Type and Number:
Japanese Patent JP5000294
Kind Code:
B2
Abstract:
There is provided a compound of Formula I wherein (I) R 1 is a selected from (i) an alkyloxyalkyl group (ii) a nitrile group, and wherein R 2 is capable of forming a hydrogen bond (iii) alkylaryl group, wherein the aryl group is substituted by other than a C1-10 group (iv) alkenylaryl group wherein the aryl group is substituted (v) alkylheteroaryl group, wherein when heteroaryl group comprises only C and N in the ring, the aryl group is substituted by other than a methyl group (vi) alkenylheteroaryl group, (vii) =N-O-alkyl or =N-O-H group (viii) branched alkenyl (ix) alkyl-alcohol group (x) amide or alkylamide wherein (a) the alkyl of the alkylamide is - CH 2 - or -CH 2 CH 2 -, (b) the amide is di-substituted and/or (c) the amide is substituted with at least one of alkylheterocycle group, alkenylheterocycle group, alkylheteroaryl group, alkenylheteroaryl group, heteroaryl group, alkylamine group, alkyloxyalkyl group, alkylaryl group, straight or branched alkyl group, (xi) -CHO so that R 1 together with R 3 provide the enol tautomer OR R 1 together with R 3 form (xii) a pyrazole wherein (a) R 4 is =N-O-alkyl or =N-O-H group, (b) the pyrazole is substituted with one of alkyl-OH group, alkyl ester group, alkyloxyalkyl group, branched alkyl group, and an amide and/or (c) the 2 position is substituted with a group selected from -OH and -O-hydrocarbyl (xiii) a heteroaryl ring to provide a compound of the formula (II) R 2 is selected from groups capable of forming a hydrogen bond , a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group and a sulphonamide group; and (III)R 3 is selected from -OH, =O, or a -C(=O)- mimetic

Inventors:
Vicker, Nigel
Lawrence, Harsani Rismar Ruchilanani
Alan, Gillian Margaret
Christian Burbert
Fisher, Delphin Sophie Marion
Puro Hit, Alan
Reed, michael john
Potter, Barry Victor Lloyd
Application Number:
JP2006505995A
Publication Date:
August 15, 2012
Filing Date:
March 22, 2004
Export Citation:
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Assignee:
Sterix limited
International Classes:
C07J1/00; A61K31/56; A61K31/565; A61K31/566; A61K31/58; A61P1/02; A61P1/04; A61P1/14; A61P1/16; A61P3/10; A61P5/14; A61P5/30; A61P7/00; A61P9/10; A61P11/02; A61P11/06; A61P13/12; A61P15/00; A61P15/06; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/10; A61P21/00; A61P21/04; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/04; A61P31/18; A61P35/00; A61P35/02; A61P35/04; A61P37/02; A61P37/04; A61P37/06; A61P37/08; A61P43/00; C07J17/00; C07J33/00; C07J41/00; C07J43/00; C07J71/00; C07J
Foreign References:
US3159656
US3243432
Other References:
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Indian J. Chem.,2003年,Vol.42B,p.166-172
Steroids,1988年,Vol.51, Nos.5-6,p.471-497
J. Med. Chem.,2000年,Vol.43, No.23,p.4465-4478
Steroids,2002年,Vol.67,p.371-377
Chemical Abstracts,Abstract No. 99:187948,(Zhongguo Yaoli Xuebao, 1983, Vol.4, No.3, p.186-191)
J. Med. Chem.,1969年,Vol.12, No.1,p.5-8
TREMBLAY M R,JOURNAL OF STEROID BIOCHEMISTRY,英国,PERGAMON PRESS PLC,1998年,V66 N4,P179-191
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita