バイオ作用性物質をバイオ粒子表面膜へ結合するための化合物、組成、および方法

Title:

バイオ作用性物質をバイオ粒子表面膜へ結合するための化合物、組成、および方法

Document Type and Number:

Japanese Patent JP3682974

Kind Code:

B2

Abstract:

Compounds are provided having the capability of binding therapeutically active substances to lipid containing bio-compatible particles, such as cells or viruses. These compounds include a bio-affecting moiety, comprising a therapeutically active substance, which is linked via a linking moiety to at least one hydrocarbon substituent selected so that the compounds is sufficiently non-polar to impart lipid binding capability to the compound. Thus, compounds of the invention are useful for site-selective delivery of therapeutic agents, and retention thereof at the selected site. Methods are provided for using various compounds of the invention in treatment of diseases or other pathological conditions. For example, methods are provided for treatment of: (1) post-angioplasty restenosis; (2) rheumatoid arthritis; (3) tumor cell proliferation, particularly tumor cells associated with ovarian cancer; and (4) psoriasis.

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Inventors:

Gregory A. Copier
Horan, Paul Kay
Gray, Brian Dee
Troutner, David Yee
Muir Head, Catherine A.
Rin, Chia En
Chess, Kamleshkuma A
You, Geezhou
Lever, Susan Gee
Baidu, Kwamenah Yi
Jensen, Bruce Dee
Sleezak, Sue Ellen

Application Number:

JP51019093A

Publication Date:

August 17, 2005

Filing Date:

November 24, 1992

Export Citation:

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Assignee:

Fanos Development Co., Ltd.

International Classes:

A61K47/30; A61K47/48; A61K49/00; A61K51/00; A61K51/04; A61K51/08; A61K51/12; C07C235/14; C07D209/10; C07D209/24; C07D219/02; C07D263/56; C07D277/64; C07D403/12; C07D495/04; C07K7/06; C07K17/02; C08B37/00; C08B37/10; C09B15/00; C09B23/00; (IPC1-7): C07D209/10; C07C235/14; C07D219/02; C07D263/56; C07D277/64; C07D403/12; C07D495/04; C07K7/06; C07K17/02; C08B37/10; C09B15/00; C09B23/00

Domestic Patent References:

JP5745455A
JP63126833A
JP63122954A
JP52114026A

Foreign References:

WO1989010758A1
WO1992009894A1

Attorney, Agent or Firm:

Aoyama Aoi
Mitsuo Tanaka

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