Title:
中枢神経系の急性及び慢性的損傷に起因した神経変性を防止するための化合物、組成物及び方法
Document Type and Number:
Japanese Patent JP3854154
Kind Code:
B2
Abstract:
The present invention provides compositions and methods for prevention and prophylaxis of neurological diseases accompanied by neuronal death. The invention includes synthesis of 5-benzylamino salicylic acid (BAS) and its derivatives. BAS and its derivatives protect cortical neurons from toxic insults by N-methyl-D-aspartate, Zn<2+>, and reactive oxygen species. Thus, the present invention provides compositions and methods for treating stroke, traumatic brain and spinal cord injury, epilepsy, and neurodegenerative diseases that are accompanied by severe neuronal loss via excitotoxicity, Zn<2+> neurotoxicity, and free radical neurotoxicity.
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Inventors:
Byan Joe Guwag
Yan Ely
Bourum Liu
Sun Woo Yun
Ho Sun Moon
Yan Ely
Bourum Liu
Sun Woo Yun
Ho Sun Moon
Application Number:
JP2001576755A
Publication Date:
December 06, 2006
Filing Date:
April 19, 2000
Export Citation:
Assignee:
Neurotech Company Limited
International Classes:
A61K31/606; C12M3/00; A61B17/42; A61B17/435; A61B19/02; A61D19/02; A61D19/04; A61K31/196; A61K31/618; A61K31/621; A61P3/10; A61P7/06; A61P19/08; A61P21/04; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P43/00; C07C229/64; C07C233/54; C07C233/81; C07C311/21; A61B
Domestic Patent References:
| JP9077651A | ||||
| JP7509490A | ||||
| JP62501703A | ||||
| JP59176239A | ||||
| JP55027110A | ||||
| JP54125632A | ||||
| JP60237041A | ||||
| JP49020197B1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita