Title:
ＢＡＣＥ１阻害剤としての化合物およびそれらの使用
Document Type and Number:
Japanese Patent JP6765681
Kind Code:
B2
Abstract:
The present invention relates to compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein X, Y, Z, Q, W, m, u, ring (A), R2, R3, R4, R5 and R6, are as defined in the specification and claims. The present invention provides a pharmaceutical composition containing the compounds of Formula (I) and a therapeutic method of treating and/or preventing Downs syndrome, 3-amyloid angiopathy, disorders associated with cognitive impairment, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegenerative diseases, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, Alzheimer's disease and/or Down syndrome, age-related macular degeneration (AMD), glaucoma, olfactory function impairment, traumatic brain injury, progressive muscle diseases, Type II diabetes mellitus and cardiovascular diseases (stroke).
Inventors:
Cherkli, Madu
Lin, Xiao-wen
Yu, Shu Qi
Fan, repin
Rajan, Yesdos Christs
Tan-Riu, Diane Dan-Sha
White, Andrew Dee
Malone, Thomas
Beresis, Richard
Lin, Xiao-wen
Yu, Shu Qi
Fan, repin
Rajan, Yesdos Christs
Tan-Riu, Diane Dan-Sha
White, Andrew Dee
Malone, Thomas
Beresis, Richard
Application Number:
JP2017555545A
Publication Date:
October 07, 2020
Filing Date:
April 20, 2016
Export Citation:
Assignee:
All genesis biotherapeutics, Inc.
International Classes:
C07D239/22; A61K31/496; A61K31/513; A61K31/5355; A61K31/5377; A61K31/541; A61K31/547; A61K31/549; A61K31/55; A61K31/553; A61K31/554; A61P3/10; A61P21/00; A61P25/16; A61P25/28; A61P27/02; C07D403/04; C07D405/04; C07D409/04; C07D409/14; C07D413/04; C07D417/04; C07D417/14; C07D471/04; C07D471/14; C07D491/048; C07D495/04; C07D513/10
Domestic Patent References:
| JP2014524472A | ||||
| JP2013507368A | ||||
| JP2014514302A | ||||
| JP2007513973A | ||||
| JP2008516945A | ||||
| JP2013533295A |
Foreign References:
| WO2008133274A1 | ||||
| WO2007049532A1 | ||||
| WO2012138734A1 |
Other References:
DATABASE REGISTRY [ONLINE] Retrieved from STN,Entered STN: 25 Feb 2014,検索日:2020年1月20日,CAS登録番号:1555426-08-8
DATABASE REGISTRY [ONLINE] Retrieved from STN,Entered STN: 25 Nov 2013,検索日:2020年1月20日,CAS登録番号:1480491-90-4
DATABASE REGISTRY [ONLINE] Retrieved from STN,Entered STN: 20 Jan 2014,検索日:2020年1月20日,CAS登録番号:1524831-87-5
DATABASE REGISTRY [ONLINE] Retrieved from STN,Entered STN: 25 Nov 2013,検索日:2020年1月20日,CAS登録番号:1480491-90-4
DATABASE REGISTRY [ONLINE] Retrieved from STN,Entered STN: 20 Jan 2014,検索日:2020年1月20日,CAS登録番号:1524831-87-5
Attorney, Agent or Firm:
Kimura Mitsuru
Taiji Morikawa
Kiyoko Ota
Yamata Uta
Etsuko Saito
Taiji Morikawa
Kiyoko Ota
Yamata Uta
Etsuko Saito