Title:
ヘッジホッグ経路調節剤としての化合物および組成物
Document Type and Number:
Japanese Patent JP4891396
Kind Code:
B2
Abstract:
The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
Inventors:
Gao Wenki
Jean Jikin
One Youngkin
Chen Die
Han Dong
U Shu
Pan sifen
Jean Jikin
One Youngkin
Chen Die
Han Dong
U Shu
Pan sifen
Application Number:
JP2009510112A
Publication Date:
March 07, 2012
Filing Date:
May 04, 2007
Export Citation:
Assignee:
IRM,LLC
International Classes:
C07C235/42; A61K31/167; A61K31/275; A61K31/40; A61K31/4433; A61K31/4453; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/495; A61K31/496; A61K31/505; A61K31/5375; A61K31/5377; A61K31/541; A61K31/55; A61K31/551; A61K31/553; A61P35/00; A61P43/00; C07C237/40; C07C255/57; C07D213/75; C07D213/81; C07D239/42; C07D241/42; C07D267/10; C07D295/12; C07D295/14; C07D295/22; C07D401/04; C07D401/12; C07D401/14; C07D405/12; C07D405/14; C07D409/14; C07D413/04
Domestic Patent References:
| JP2008516989A | 2008-05-22 | |||
| JP2008511675A | 2008-04-17 |
Foreign References:
| WO2005030206A1 | 2005-04-07 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Aoyama Aoi
Mitsutaka Iwasaki
Aoyama Aoi
Mitsutaka Iwasaki