治療剤の細胞内送達のための化合物及び組成物

Title:

治療剤の細胞内送達のための化合物及び組成物

Document Type and Number:

Japanese Patent JP7167049

Kind Code:

B2

Abstract:

The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

More Like This:

WO/2023/186171	CATIONIC LIPID, LIPOSOME, LIPID NANOPARTICLE, AND USE
JP2022129896	ORGANIC AMMONIUM SALT HAVING PHOSPHONATE OR PHOSPHINATE ANION, AND COMPOSITION CAPABLE OF FORMING THE SALT

Inventors:

Benenato, Kelly E.
Kumarasinghe, Elarahewage Satyajit
Corne Vice, Mark

Application Number:

JP2019550732A

Publication Date:

November 08, 2022

Filing Date:

March 15, 2018

Export Citation:

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Assignee:

ModernaTX,Inc.

International Classes:

C07C229/12; A61K9/14; A61K31/7088; A61K31/7105; A61K39/00; A61K47/18; A61K47/20; A61K47/22; A61K47/24; A61K47/28; A61K47/34; A61K48/00; A61P3/00; A61P3/10; A61P9/00; A61P13/12; A61P25/00; A61P25/28; A61P31/00; A61P35/00; A61P37/02; C07C279/12; C07C311/05; C07D207/263; C07D209/48; C07D233/24; C07D233/72; C07D239/47; C07D239/553; C07D249/04; C07D263/20; C07D265/32; C07D271/10; C07D277/42; C07D295/13; C07D295/135; C07D487/04

Domestic Patent References:

JP6948313B2

Foreign References:

WO2016176330A1
WO2013089152A1

Other References:

Chem. Commun.,2016年,52,9438-9441

Attorney, Agent or Firm:

Makoto Onda
Hironobu Onda
Atsushi Honda
Nakamura Miki

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