Title:
化合物、診断薬、核磁気共鳴分析方法、核磁気共鳴イメージング方法、質量分析方法及び質量分析イメージング方法
Document Type and Number:
Japanese Patent JP4954165
Kind Code:
B2
Abstract:
To produce a labeled compound for a selected biological substance not using a radioisotope atom which has a risk of exposure to radioactivity and limitation on handling time but using a stable isotope atom; and that the labeled compound can be measured with good sensitivity separably from naturally occurring compounds of the selected biological substance which are substituted with the stable isotope atom. Choline as a biological substance is labeled by substituting the nitrogen atom of the quaternary ammonium group and all the carbon atoms of the methyl group attached to the nitrogen atom with respective isotopes 15N and 13C and used as a diagnostic agent.
Inventors:
Kimihiro Yoshimura
Fumio Yamauchi
Katsuaki Hisa
Tetsuya Yano
Masahiro Shirakawa
Yasuhiro Aoyama
Fumio Yamauchi
Katsuaki Hisa
Tetsuya Yano
Masahiro Shirakawa
Yasuhiro Aoyama
Application Number:
JP2008228439A
Publication Date:
June 13, 2012
Filing Date:
September 05, 2008
Export Citation:
Assignee:
Canon Inc
International Classes:
C07C215/40; A61B5/055; A61K49/00; C07C219/06; C07F9/09; G01N24/12; G01N27/62; G01R33/28; G01R33/465
Foreign References:
| WO1998057578A1 | ||||
| WO2006082108A2 |
Other References:
LUO,R. et al.,NMR assignment of the R2 domain of pneumococcal choline binding protein A (CbpA),Journal of Biomolecular NMR,2005年,Vol.32, No.1,p.93
WATTERSON,A.C. et al.,Syntheses of nitrogen-15-labeled ion-pair comonomers,Polymer Preprints(American Chemical Society, Division of Polymer Chemistry),1990年,Vol.31, No.1,p.492-493
AKOKA,S. et al.,Molecular order, dynamics, and ionization state of phosphatidylethanolamine bilayers as studied by nitrogen-15 NMR,Biochemistry,1986年,Vol.25, No.22,p.6972-6977
ANDERSON,M.A. et al.,Hydrolysis of Phosphotriesters: Determination of Transition States in Parallel Reactions by Heavy-Atom Isotope Effects,Journal of the American Chemical Society,2001年,Vol.123, No.38,p.9246-9253
DESMOULIN,F. et al.,Application of reverse-DEPT polarization transfer pulse sequence to study the metabolism of carbon-13-labeled substrates in perfused organs by protein NMR spectroscopy,Magnetic Resonance in Medicine,1990年,Vol.15, No.3,p.456-461
WATTERSON,A.C. et al.,Syntheses of nitrogen-15-labeled ion-pair comonomers,Polymer Preprints(American Chemical Society, Division of Polymer Chemistry),1990年,Vol.31, No.1,p.492-493
AKOKA,S. et al.,Molecular order, dynamics, and ionization state of phosphatidylethanolamine bilayers as studied by nitrogen-15 NMR,Biochemistry,1986年,Vol.25, No.22,p.6972-6977
ANDERSON,M.A. et al.,Hydrolysis of Phosphotriesters: Determination of Transition States in Parallel Reactions by Heavy-Atom Isotope Effects,Journal of the American Chemical Society,2001年,Vol.123, No.38,p.9246-9253
DESMOULIN,F. et al.,Application of reverse-DEPT polarization transfer pulse sequence to study the metabolism of carbon-13-labeled substrates in perfused organs by protein NMR spectroscopy,Magnetic Resonance in Medicine,1990年,Vol.15, No.3,p.456-461
Attorney, Agent or Firm:
Akio Miyazaki
Ishibashi Masayuki
Masaaki Ogata
Ishibashi Masayuki
Masaaki Ogata