Title:
5-ヒドロキシトリプタミンおよびノルエピネフリンの再取込みの阻害のための、またはうつ病障害の治療のための化合物、その製造方法ならびにその使用
Document Type and Number:
Japanese Patent JP5080458
Kind Code:
B2
Abstract:
The present invention discloses compounds of formula (I), their optical isomers or pharmaceutically acceptable salts thereof, their preparation and uses thereof, wherein the definitions of R1, R2, R3 and R4 are shown in the description. These compounds are optical isomers or racemic mixtures. After these compounds are uptaken, they are metabolically transformated in vivo into 1-[2-dimethylamino-1-(4-hydroxyphenyl)-ethyl]-cyclohexanol that has neuropharmacological activity, by interrupting reuptake of 5-hydroxytryptamine (5-HT) and/or norepinephrine (NA), which is used for treating diseases associated with central nerve system, such as depression, etc.
Inventors:
Jean, Lupine
Application Number:
JP2008516114A
Publication Date:
November 21, 2012
Filing Date:
June 16, 2006
Export Citation:
Assignee:
SHANDONG LUYE PHARMACEUTICAL CO., LTD.
Li, Youshin
Li, Youshin
International Classes:
C07C219/28; A61K31/137; A61P25/00; A61P25/04; A61P43/00
Domestic Patent References:
| JP2003501344A | ||||
| JP2003524613A |
Foreign References:
| CN1706813A | ||||
| US20020037922 |
Attorney, Agent or Firm:
Makoto Nakamura
Kurata Masatoshi
Takashi Mine
Yoshihiro Fukuhara
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Katsu Sunagawa
Kurata Masatoshi
Takashi Mine
Yoshihiro Fukuhara
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Katsu Sunagawa