Title:
白色脂肪組織の褐色化を誘導するための化合物および方法
Document Type and Number:
Japanese Patent JP6483272
Kind Code:
B2
Abstract:
The present invention provides a compound for inducing browning of white adipose tissue in vitro and in vivo of formula I, the preparation method thereof, as well as a composition comprising the same. Further, the present invention also relates to the use of the compound and the method to treat metabolic disorders, such as obesity and diabetes.
Inventors:
Jen, Baishan
Ne, Tao
Wenling, Jiao
Tsou
Din, Chen
Din, Shen
Wu, Dong Hai
Ne, Tao
Wenling, Jiao
Tsou
Din, Chen
Din, Shen
Wu, Dong Hai
Application Number:
JP2017543800A
Publication Date:
March 13, 2019
Filing Date:
February 17, 2015
Export Citation:
Assignee:
Guanzhou Institute of Biomedical and Health, Chinese Academy of Sciences
International Classes:
C07D417/12; A61K31/426; A61K31/427; A61K31/428; A61K31/4439; A61K31/4545; A61K31/4725; A61K31/496; A61K31/5377; A61P3/04; A61P3/10; A61P43/00; C07D417/14
Domestic Patent References:
| JP2013530927A | ||||
| JP2010540667A | ||||
| JP2010533147A | ||||
| JP2009524670A |
Foreign References:
| WO2013033037A1 | ||||
| WO2005099673A1 | ||||
| WO2012015715A1 | ||||
| WO2003062215A1 | ||||
| WO2009099195A1 |
Other References:
European Journal of Medicinal Chemistry,,2014年,87,p.643-656
Journal of Virology,2010年,84(7),p.3408-3412
Department of Pharmacology & Molecular Sciences, Johns Hopkins Bioorganic & Medicinal Chemistry Letters,2013年,23(9),p.2733-2737
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry,1979年,17B(5),p.519-521
Bioorganic & Medicinal Chemistry Letters,2008年,18(19),p.5316-5319
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REGISTRY(STN)[online],2002.01.02[検索日 2018.08.14], CAS登録番号 380174-17-4
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REGISTRY(STN)[online],2011.08.28[検索日 2018.08.14], CAS登録番号 1324541-73-2
REGISTRY(STN)[online],2001.01.22[検索日 2018.08.14], CAS登録番号 315706-20-8
REGISTRY(STN)[online],2004.06.28[検索日 2018.08.14], CAS登録番号 700803-18-5
REGISTRY(STN)[online],2008.12.24[検索日 2018.08.14], CAS登録番号 1089559-86-3
REGISTRY(STN)[online],2008.06.24[検索日 2018.08.14], CAS登録番号 1030100-85-6
REGISTRY(STN)[online],2005.02.15[検索日 2018.08.14], CAS登録番号 831251-72-0
Journal of Virology,2010年,84(7),p.3408-3412
Department of Pharmacology & Molecular Sciences, Johns Hopkins Bioorganic & Medicinal Chemistry Letters,2013年,23(9),p.2733-2737
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry,1979年,17B(5),p.519-521
Bioorganic & Medicinal Chemistry Letters,2008年,18(19),p.5316-5319
REGISTRY(STN)[online],2008.08.22[検索日 2018.08.14], CAS登録番号 1042853-24-6,1042868-31-4
REGISTRY(STN)[online],2009.07.31[検索日 2018.08.14], CAS登録番号 1171310-23-8
REGISTRY(STN)[online],2002.01.02[検索日 2018.08.14], CAS登録番号 380174-17-4
REGISTRY(STN)[online],2003.03.06[検索日 2018.08.14], CAS登録番号 497083-40-6
REGISTRY(STN)[online],2001.03.19[検索日 2018.08.14], CAS登録番号 327971-37-9
REGISTRY(STN)[online],2011.08.28[検索日 2018.08.14], CAS登録番号 1324541-73-2
REGISTRY(STN)[online],2001.01.22[検索日 2018.08.14], CAS登録番号 315706-20-8
REGISTRY(STN)[online],2004.06.28[検索日 2018.08.14], CAS登録番号 700803-18-5
REGISTRY(STN)[online],2008.12.24[検索日 2018.08.14], CAS登録番号 1089559-86-3
REGISTRY(STN)[online],2008.06.24[検索日 2018.08.14], CAS登録番号 1030100-85-6
REGISTRY(STN)[online],2005.02.15[検索日 2018.08.14], CAS登録番号 831251-72-0
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