NF-κBの活性化を調節する化合物および方法

Japanese Patent JP4633259

B2

Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated IκBα and/or IκBβ. Such compositions may be used for treating diseases associated with NF-κB activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.

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Manning, Anthony, M.
Mercurio, Frank
Amit, Sharon
Ben-Nellier, Inon
Davis, Matty
Hatsubai, ada
Ravon, Iris
Yaron, Abraham

JP2000586881A

February 16, 2011

December 09, 1999

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Signal Pharmaceuticals, LRC
Isum Research Development Company of the Hebrew University of Jerusalem

C12N15/09; A61K31/713; A61K38/53; A61K39/395; A61K48/00; A61P29/00; A61P31/12; A61P35/00; A61P37/00; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/00; C12P21/08; C12Q1/25; A61K38/00

Ishikawa,K., et al., "Accession: AB014596 [gi: 3327205], Definition: Homo sapiens mRNA for KIAA0696 protein, partial cds.",NCBI Nucleotide,15-JUL-1998 uploaded,[retrieved on 9-SEP-2009] Retrieved from the Internet:
Mol.Cell,1998,1(4),p.565-74

Hatta International Patent Corporation

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