Title:
化合物、医薬組成物、及び神経変性疾患の治療におけるそれらの使用
Document Type and Number:
Japanese Patent JP6704355
Kind Code:
B2
Abstract:
The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.
Inventors:
Patricia Melnik
Patrick Wermels
Pascal Karato
Benedict Oxon Bull-Vanteem
Helen Zephyr
Marion Donier-Marechal
Patrick Wermels
Pascal Karato
Benedict Oxon Bull-Vanteem
Helen Zephyr
Marion Donier-Marechal
Application Number:
JP2016573483A
Publication Date:
June 03, 2020
Filing Date:
June 15, 2015
Export Citation:
Assignee:
Universite de Lille 2 Drawer et Sante
Center Hospitalier Regionale Universitaire de Lille
Center Hospitalier Regionale Universitaire de Lille
International Classes:
C07C211/14; A61K31/137; A61K31/165; A61K31/166; A61K31/167; A61K31/18; A61K31/4035; A61K51/04; A61P21/02; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P43/00; C07C233/78; C07C235/42; C07C237/06; C07C237/30; C07C255/57; C07C311/16; C07D209/44
Domestic Patent References:
| JP7188139A | ||||
| JP2138162A | ||||
| JP2006528971A |
Foreign References:
| WO2012177618A1 | ||||
| FR2729146A1 | ||||
| US4010282 | ||||
| US2241498 | ||||
| WO1992022279A2 |
Other References:
Fitzsimmons, Jonathan M.; Lever, John R.; Lever, Susan Z.,Synthesis and σ1 receptor binding of halogenated N,N'-diphenethylethylenediamines,Med Chem,2011年,1(102)
Sim, Edith; Stanley, Lesley; Gill, Edward W.; Jones, Alison,Metabolites of procainamide and practolol inhibit complement components C3 and C4,Biochemical Journal,1988年,251,323-326
Bieraugel, H.; Plemp, R.; Hiemstra, H. C.; Pandit, U. K.,Models of folate coenzymes - VII. Synthesis and carbon transfer reactions of N5,N10-methenyl and N5,N10-methylenetetrahydrofolate models,Tetrahedron,1983年,Vol.39 No.23,3971-3979
Dal Maso, Monica; Orelli, Liliana; Perillo, Isabel A.,Ring opening reaction of 1,2-diaryl-3-methyl-1,4,5,6- tetrahydropyrimidinium salts with metal hydride complexes,Journal of Heterocyclic Chemistry,1994年,Vol.31,25-31
Schoenenberger, Helmut; Petter, Alfred; Kuehling, Volker; Bindl, Ludwig,Synthesis and pharmacological test of N-(3'-methoxybenzamidomethyl)-D-norephedrine and analogous compounds,Archiv der Pharmazie,1976年,309/76,289-301
REGISTRY(STN)[online],2008.07.27[検索日2019.01.18]CAS登録番号1036485-99-0, 1,3-Propanediamine, N3-[(4-chlorophenyl)methyl]-N1-methyl-N1-(phenylmethyl)- (CA INDEX NAME)
REGISTRY(STN)[online],2008.08.24[検索日2019.01.18]CAS登録番号1043061-65-9, Benzamide, 4-methoxy-N-[3-[methyl(phenylmethyl)amino]propyl]-(CA INDEX NAME)
REGISTRY(STN)[online],2008.08.24[検索日2019.01.18]CAS登録番号1043103-24-7, Benzamide, 3-chloro-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2008.08.24[検索日2019.01.18]CAS登録番号1043138-50-6, Benzamide, 3-methoxy-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2008.12.28[検索日2019.01.18]CAS登録番号1090777-15-3, Benzamide, 4-cyano-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2011.01.12[検索日2019.01.18]CAS登録番号1259181-34-4, Benzamide, 4-fluoro-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2011.04.28[検索日2019.01.18]CAS登録番号1287146-98-8, Benzamide, 2-bromo-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2011.05.17[検索日2019.01.18]CAS登録番号1295795-73-1, Benzamide, 3-bromo-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2011.08.28[検索日2019.01.18]CAS登録番号1324492-71-8, Benzamide, 2-chloro-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2011.09.04[検索日2019.01.18]CAS登録番号1327827-70-2, Benzamide, 4-chloro-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2011.09.04[検索日2019.01.18]CAS登録番号1328023-71-7, Benzamide, 4-bromo-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2011.09.05[検索日2019.01.18]CAS登録番号1328397-48-3, Benzamide, N-[3-[methyl(phenylmethyl)amino]propyl]-4-(trifluoromethyl)-(CA INDEX NAME)
REGISTRY(STN)[online],2011.09.06[検索日2019.01.18]CAS登録番号1328902-85-7, Benzenesulfonamide, 4-chloro-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2011.09.09[検索日2019.01.18]CAS登録番号1330577-08-6, Benzamide, 3-(dimethylamino)-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2012.04.16[検索日2019.01.18]CAS登録番号1369055-08-2, Benzamide, 4-(1,1-dimethylethyl)-N-[3-[methyl(phenylmethyl)amino]propyl]-(CA INDEX NAME)
REGISTRY(STN)[online],2012.08.12[検索日2019.01.18]CAS登録番号1389760-28-4, Benzamide, 4-chloro-N-[2-[methyl(phenylmethyl)amino]ethyl]- (CA INDEX NAME)
Sim, Edith; Stanley, Lesley; Gill, Edward W.; Jones, Alison,Metabolites of procainamide and practolol inhibit complement components C3 and C4,Biochemical Journal,1988年,251,323-326
Bieraugel, H.; Plemp, R.; Hiemstra, H. C.; Pandit, U. K.,Models of folate coenzymes - VII. Synthesis and carbon transfer reactions of N5,N10-methenyl and N5,N10-methylenetetrahydrofolate models,Tetrahedron,1983年,Vol.39 No.23,3971-3979
Dal Maso, Monica; Orelli, Liliana; Perillo, Isabel A.,Ring opening reaction of 1,2-diaryl-3-methyl-1,4,5,6- tetrahydropyrimidinium salts with metal hydride complexes,Journal of Heterocyclic Chemistry,1994年,Vol.31,25-31
Schoenenberger, Helmut; Petter, Alfred; Kuehling, Volker; Bindl, Ludwig,Synthesis and pharmacological test of N-(3'-methoxybenzamidomethyl)-D-norephedrine and analogous compounds,Archiv der Pharmazie,1976年,309/76,289-301
REGISTRY(STN)[online],2008.07.27[検索日2019.01.18]CAS登録番号1036485-99-0, 1,3-Propanediamine, N3-[(4-chlorophenyl)methyl]-N1-methyl-N1-(phenylmethyl)- (CA INDEX NAME)
REGISTRY(STN)[online],2008.08.24[検索日2019.01.18]CAS登録番号1043061-65-9, Benzamide, 4-methoxy-N-[3-[methyl(phenylmethyl)amino]propyl]-(CA INDEX NAME)
REGISTRY(STN)[online],2008.08.24[検索日2019.01.18]CAS登録番号1043103-24-7, Benzamide, 3-chloro-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2008.08.24[検索日2019.01.18]CAS登録番号1043138-50-6, Benzamide, 3-methoxy-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2008.12.28[検索日2019.01.18]CAS登録番号1090777-15-3, Benzamide, 4-cyano-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2011.01.12[検索日2019.01.18]CAS登録番号1259181-34-4, Benzamide, 4-fluoro-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2011.04.28[検索日2019.01.18]CAS登録番号1287146-98-8, Benzamide, 2-bromo-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2011.05.17[検索日2019.01.18]CAS登録番号1295795-73-1, Benzamide, 3-bromo-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2011.08.28[検索日2019.01.18]CAS登録番号1324492-71-8, Benzamide, 2-chloro-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2011.09.04[検索日2019.01.18]CAS登録番号1327827-70-2, Benzamide, 4-chloro-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2011.09.04[検索日2019.01.18]CAS登録番号1328023-71-7, Benzamide, 4-bromo-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2011.09.05[検索日2019.01.18]CAS登録番号1328397-48-3, Benzamide, N-[3-[methyl(phenylmethyl)amino]propyl]-4-(trifluoromethyl)-(CA INDEX NAME)
REGISTRY(STN)[online],2011.09.06[検索日2019.01.18]CAS登録番号1328902-85-7, Benzenesulfonamide, 4-chloro-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2011.09.09[検索日2019.01.18]CAS登録番号1330577-08-6, Benzamide, 3-(dimethylamino)-N-[3-[methyl(phenylmethyl)amino]propyl]- (CA INDEX NAME)
REGISTRY(STN)[online],2012.04.16[検索日2019.01.18]CAS登録番号1369055-08-2, Benzamide, 4-(1,1-dimethylethyl)-N-[3-[methyl(phenylmethyl)amino]propyl]-(CA INDEX NAME)
REGISTRY(STN)[online],2012.08.12[検索日2019.01.18]CAS登録番号1389760-28-4, Benzamide, 4-chloro-N-[2-[methyl(phenylmethyl)amino]ethyl]- (CA INDEX NAME)
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe