Title:
対象の表面をモニターし、処置するための化合物、システムおよび方法
Document Type and Number:
Japanese Patent JP6470748
Kind Code:
B2
Abstract:
Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.
Inventors:
Evans, Connor, Elle
Apiou, Gabriella
Nicholas, Alexander, Jay
Rusakis, Emanuel
Li, Zonghi
Apiou, Gabriella
Nicholas, Alexander, Jay
Rusakis, Emanuel
Li, Zonghi
Application Number:
JP2016525348A
Publication Date:
February 13, 2019
Filing Date:
June 13, 2014
Export Citation:
Assignee:
The General Hospital Corporation
International Classes:
C09B47/00; C07D487/22; C09B67/08; C09K11/06
Domestic Patent References:
| JP2009162871A | ||||
| JP2000515858A |
Other References:
Jurgen-Hinrich Fuhrhop,Djamshid Hosseinpour,Hexadecahydro-29H,31H-tetrabenzo[b,g,l,q]porphin and -octayl Octaacetate,Liebigs Annalen der Chemie,1985年,vol.1985,no.4,pages 689-695
V.N.Kopranenkov et al.,SYNTHESIS AND ELECTRONIC ABSORPTION SPECTRA OF SUBSTITUTED TETRABENZOPORPHINS,CHEMISTRY OF HETEROCYCLIC COMPOUNDS,1988年 6月,vol.24,no.6,pages 630-637
Filatov et al.,The synthesis of new tetrabenzo- and tetranaphthoporphyrins via the addition reactions of 4,7-dihydroisoindole,Tetrahedron,2011年,vol.67,pages 3559-3566
V.N.Kopranenkov et al.,SYNTHESIS AND ELECTRONIC ABSORPTION SPECTRA OF SUBSTITUTED TETRABENZOPORPHINS,CHEMISTRY OF HETEROCYCLIC COMPOUNDS,1988年 6月,vol.24,no.6,pages 630-637
Filatov et al.,The synthesis of new tetrabenzo- and tetranaphthoporphyrins via the addition reactions of 4,7-dihydroisoindole,Tetrahedron,2011年,vol.67,pages 3559-3566
Attorney, Agent or Firm:
Fumio Takino
Takao Kawasaki
Toshiaki Tsuda
Yasuhiro Fukuda
Takao Kawasaki
Toshiaki Tsuda
Yasuhiro Fukuda
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