Title:
シャペロン介在性オートファジー調節剤として有用な化合物
Document Type and Number:
Japanese Patent JP7262141
Kind Code:
B2
Abstract:
The present invention relates to 2-phenyl-6-halo-quinoxaline derivatives of Formula Ias chaperone-mediated autophagy (CMA) modulators for the treatment of e.g. Parkingson's disease
Inventors:
Anna Maria Cuervo
Evlipidis Gavaciotis
Evlipidis Gavaciotis
Application Number:
JP2021509972A
Publication Date:
April 21, 2023
Filing Date:
August 30, 2018
Export Citation:
Assignee:
ALBERT EINSTEIN COLLEGE OF MEDICINE
International Classes:
A61K31/498; C07D241/42; A61P1/16; A61P3/00; A61P3/10; A61P9/00; A61P11/00; A61P13/12; A61P21/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P37/02; A61P43/00
Domestic Patent References:
| JP2007535569A | ||||
| JP2013518816A |
Foreign References:
| US20150166492 | ||||
| WO2016111957A1 |
Other References:
Ahmadi Sabegh, Mehdi 他,The regioselective catalyst-free synthesis of bis-quinoxalines and bis-pyrido[2,3-b]pyrazines by double condensation of 1,4-phenylene-bis-glyoxal with 1,2-diamines,Heterocyclic Communications,2018年,24(4),,193-196,DOI:10.1515/hc-2018-0039
Zhang, Jinzhong 他,Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A,Journal of Biological Chemistry,2017年,292(25),,10328-10346,DOI:10.1074/jbc.M116.764076
Zhang, Jinzhong 他,Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A,Journal of Biological Chemistry,2017年,292(25),,10328-10346,DOI:10.1074/jbc.M116.764076
Attorney, Agent or Firm:
Yamato Kento
Yasushi Ochiai
Yasushi Ochiai