Title:
メラノコルチン受容体のモジュレーターとして有用な化合物及びそれを含む製薬組成物
Document Type and Number:
Japanese Patent JP2005511475
Kind Code:
A
Abstract:
Compounds having the formula (I), G is a novel side chain selected from C2-6alkenyl, A3-aryl, -OR18, heteroaryl, A1-cyano, A2-OR17, A1-C(-O)R18, A1-CO2R18, A1-C(-O)NR18R19, A1-OC(-O)R18, A1-NR18C(-O)R19, A1-OC(-O)NR18R19, A1-NR18CO2R19, A1-NR18SO2R17, A1-SO2R17, A1-NR20C(-O)NR18R19, and A1-SR18; or when y is 0 or when W is not NHR22, G may be A1-heterocyclo, wherein A1 is a bond, C1-6alkylene or C2-alkenylene, A2 is C1-6alkylene or C2-6alkenylene, and A3 is C2-6alkenylene; W is selected from -NR21R22, -OR23, -NR21C(-O)R24, -NR21CO2R24, amidino, guanidino, or a heteroaryl, heterocyclo or C3-7cycloalkyl as defined in the specification, and X and R1 through R24 are as defined in the specification, are effective as modulators of melanocortin-receptors, particularly MC-1R and MC-4R.
Inventors:
You, Gikue
John McCarre
Harpin, Timothy
Lawrence, Earl Michael
Morton, George Sea
Rules, legian
Poindexter, Graham S
Rudger, Edward H
Gee Vault, curl
John McCarre
Harpin, Timothy
Lawrence, Earl Michael
Morton, George Sea
Rules, legian
Poindexter, Graham S
Rudger, Edward H
Gee Vault, curl
Application Number:
JP2002569831A
Publication Date:
April 28, 2005
Filing Date:
March 02, 2002
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K31/4178; A61K31/438; A61K31/451; A61K31/454; A61K31/4545; A61K31/47; A61K31/4709; A61K31/4725; A61K31/4747; A61K31/496; A61K31/501; A61K31/506; A61K31/519; A61K31/527; A61K31/537; A61K31/5377; A61K31/5415; A61K31/55; A61P1/00; A61P1/04; A61P1/16; A61P1/18; A61P3/02; A61P3/04; A61P3/06; A61P3/10; A61P5/14; A61P5/16; A61P7/00; A61P7/02; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/02; A61P11/06; A61P11/08; A61P13/12; A61P15/00; A61P15/08; A61P15/10; A61P17/00; A61P17/04; A61P17/06; A61P17/14; A61P17/16; A61P19/02; A61P19/10; A61P21/00; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P27/16; A61P29/00; A61P31/04; A61P31/06; A61P31/18; A61P31/20; A61P33/06; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07D211/32; C07D211/34; C07D211/58; C07D211/60; C07D233/64; C07D211/62; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/12; C07D405/14; C07D409/14; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D471/10; C07D487/04; C07D491/10; C07D495/04; C07D498/10; C07K5/06; C07K5/078; A61K38/00; (IPC1-7): C07D211/32; A61K31/4178; A61K31/438; A61K31/451; A61K31/454; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/4747; A61K31/496; A61K31/506; A61K31/519; A61K31/527; A61K31/537; A61K31/5415; A61K31/55; A61P1/00; A61P1/16; A61P1/18; A61P3/02; A61P3/04; A61P3/06; A61P3/10; A61P5/14; A61P7/00; A61P7/02; A61P9/10; A61P9/12; A61P11/00; A61P11/02; A61P11/06; A61P11/08; A61P13/12; A61P15/00; A61P15/08; A61P15/10; A61P17/00; A61P17/04; A61P17/06; A61P17/14; A61P19/02; A61P19/10; A61P21/00; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P29/00; A61P31/04; A61P31/06; A61P31/18; A61P33/06; A61P35/00; A61P37/06; A61P43/00; C07D211/34; C07D233/64; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/12; C07D405/14; C07D409/14; C07D413/14; C07D417/12; C07D417/14; C07D471/10; C07D491/10; C07D495/04; C07D498/10
Attorney, Agent or Firm:
Takehiko Saito
Yasuyuki Hata
Yasuyuki Hata