システインプロテアーゼの可逆性インヒビターとして有用な化合物

Japanese Patent JP2005504827

A

Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R₁, R₂, R₃, R₄, R₅, R₆, R₈, R₉ and X are defined herein. The compounds are useful for treating autoimmune and other diseases. Also disclosed are processes for making such novel compounds

Beccary younes
Hicky Eugene Earl
Wee Min Liu
Patel Usha Earl
Spero Dennis Marie
Sansan Shin
Thomson David S
Ward Yancey Dee
Young Eric Earl Earl

JP2003532454A

February 17, 2005

September 27, 2002

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Boehringer Ingelheim Pharmaceuticals, Inc.

C07D295/12; A61K31/277; A61K31/341; A61K31/351; A61K31/428; A61K31/517; A61K31/536; A61K31/5375; A61K31/5377; A61P1/04; A61P3/10; A61P5/14; A61P9/10; A61P11/06; A61P13/12; A61P15/00; A61P17/00; A61P17/06; A61P19/02; A61P19/10; A61P21/04; A61P25/00; A61P25/28; A61P29/00; A61P37/00; A61P37/02; A61P37/06; A61P43/00; C07C257/20; C07C269/06; C07C271/20; C07C271/64; C07C319/20; C07C323/41; C07C323/60; C07D211/22; C07D213/30; C07D213/57; C07D239/80; C07D263/32; C07D265/24; C07D275/06; C07D277/30; C07D295/14; C07D295/215; C07D307/12; C07D307/54; C07D309/08; C07D309/12; C07D333/24; C07D401/04; C07D401/06; (IPC1-7): C07C257/20; A61K31/277; A61K31/341; A61K31/351; A61K31/428; A61K31/517; A61K31/536; A61K31/5375; A61K31/5377; A61P1/04; A61P3/10; A61P5/14; A61P9/10; A61P11/06; A61P13/12; A61P15/00; A61P17/00; A61P17/06; A61P19/02; A61P19/10; A61P21/04; A61P25/00; A61P25/28; A61P29/00; A61P37/02; A61P37/06; A61P43/00; C07C269/06; C07C271/20; C07C319/20; C07C323/41; C07D211/22; C07D213/30; C07D239/80; C07D265/24; C07D275/06; C07D295/12; C07D295/14; C07D307/12; C07D309/08; C07D309/12; C07D401/04; C07D401/06

Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama

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