Title:
抗HCV作用を有する化合物およびその製法
Document Type and Number:
Japanese Patent JP4068639
Kind Code:
B2
Abstract:
The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its having a high degree of replication inhibitory activity against HCV, its production method, an intermediate compound useful for its production and a pharmaceutical composition containing these compounds, and the present invention relates to a compound represented by the formula (I):
(wherein A represents -(CH 2 ) n -, etc.; B represents -(C=O)-, etc.; D represents -(CH 2 ) m -R', etc.; E represents a hydrogen atom, etc.; G represents -(CH 2 ) p -J, etc.; bond Q represents a single bond or double bond; and R 1 , R 2 and R 3 may be the same or different and each represent a hydrogen atom, etc.), a prodrug thereof or a pharmaceutically acceptable salt thereof.
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Inventors:
Masayuki Sudo
Takuo Tsukuda
Maya Mabuchi
Kenichi Kawasaki
Murata Tsuyoshi
Shiro Watanabe
Hiroshi Fukuda
Ryo Komiyama
Tadakatsu Hayase
Takuo Tsukuda
Maya Mabuchi
Kenichi Kawasaki
Murata Tsuyoshi
Shiro Watanabe
Hiroshi Fukuda
Ryo Komiyama
Tadakatsu Hayase
Application Number:
JP2005511532A
Publication Date:
March 26, 2008
Filing Date:
July 09, 2004
Export Citation:
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
C07C235/76; A61K31/195; A61K31/201; A61K31/216; A61K31/27; A61K31/277; A61K31/381; A61K31/405; A61K31/41; A61K31/4192; A61K31/4402; A61K31/4406; A61K31/445; A61K31/505; A61K31/5375; A61P31/12; A61P31/18; C07C247/16; C07C255/54; C07C255/60; C07C271/22; C07C279/18; C07C311/08; C07C311/37; C07C317/32; C07C321/28; C07D211/46; C07D213/30; C07D213/36; C07D213/55; C07D213/64; C07D213/65; C07D239/26; C07D239/34; C07D249/06; C07D261/08; C07D295/14; C07D333/24
Domestic Patent References:
| JP7173123A |
Foreign References:
| WO1994018157A1 | ||||
| WO1998056755A1 |
Other References:
Tetrahedron Letters,1998年,Vol.39, No.8,p.877-880
第39回天然有機化合物討論会講演要旨集,1997年,第409-414頁
Journal of Antibiotics,1997年,Vol.50, No.4,p.339-343
Journal of Antibiotics,1997年,Vol.50, No.4,p.334-338
第39回天然有機化合物討論会講演要旨集,1997年,第409-414頁
Journal of Antibiotics,1997年,Vol.50, No.4,p.339-343
Journal of Antibiotics,1997年,Vol.50, No.4,p.334-338
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda