Title:
薬物動態特性の改善されたコンプスタチンアナログ
Document Type and Number:
Japanese Patent JP6676589
Kind Code:
B2
Abstract:
Compounds comprising peptides capable of binding C3 protein and inhibiting complement activation are disclosed. The compounds comprise compstatin analogs in which the N-terminus contains an added or substituted component that improves (1) the peptide's binding affinity to C3 or its fragments, (2) the peptide's solubility in aqueous liquids, (3) the peptide's plasma stability, (4) the peptide's in vivo retention and/or (5) the peptide's bioavailability, as compared with an unmodified compstatin peptide under equivalent conditions. Pharmaceutical compositions and methods of using the compounds are also disclosed.
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Inventors:
John Di Rambris
Chui Hong Chan
Daniel Ricklin
Chui Hong Chan
Daniel Ricklin
Application Number:
JP2017146396A
Publication Date:
April 08, 2020
Filing Date:
July 28, 2017
Export Citation:
Assignee:
AstraZeneca UK Limited
International Classes:
C07K7/08; A61K38/12; A61P11/00; A61P11/02; A61P13/02; A61P17/06; A61P25/00; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P31/06; A61P35/00; A61P37/08; A61P43/00
Domestic Patent References:
| JP6249949B2 | ||||
| JP2009517476A | ||||
| JP2014531432A |
Foreign References:
| WO2010135717A1 | ||||
| WO2012040259A1 | ||||
| WO2011163394A1 |
Other References:
M.Katragadda, et al., J Med Chem., 2006, 49, pp4616-4622
T.L.Chiu, et al., Chem Biol Drug Des., 2008, 72(2), pp249-256
T.L.Chiu, et al., Chem Biol Drug Des., 2008, 72(2), pp249-256
Attorney, Agent or Firm:
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Nagatoshi Shinagawa
Yasushi Morimoto