Title:
ヒスタミン-3受容体リガンドとしての縮合二環式置換アミン
Document Type and Number:
Japanese Patent JP4874111
Kind Code:
B2
Abstract:
Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands and methods for using such compounds and compositions. X is O, S, NH, or N(alkyl); Y, and Y' are each independently selected from the group consisting of CH, CF, and N; Z is C or N, provided that when X is O or S, Z is N; one of R 1 and R 2 is selected from the group consisting of aryl, heteroaryl, and heterocycle; the other of R 1 and R 2 is selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, cycloalkyl, halo, cyano, and thioalkoxy; R 3 is absent when Z is N and, when present, R 3 is selected from the group consisting of hydrogen, methyl, alkoxy, halo and cyano; R 4 and R 5 are each independently selected from the group consisting of alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, and cycloalkylalkyl, or R 4 and R 5 taken together with the nitrogen atom to which each is attached form a non-aromatic ring L is -[C(R 15 )(R 16 )]n-; m is an integer from 0-3; and n is an integer from 2-3.
or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, wherein:
X is O,S,NH,or N(alkyl);
Y, and Y' are each independently selected from the group consisting of CH, CF, and N;
Z is C or N, provided that when X is O or S, Z is N;
one of R 1 and R 2 is selected from the group consisting of aryl, hetereoaryl, and heterocycle.
Inventors:
Cowart, Marlon Day
Kuu, Inn-Inn
Jiang, Sou-jien
Fernando, Denny Pee
Greem, Tamothy A.
Robert A. Altenberg
Kuu, Inn-Inn
Jiang, Sou-jien
Fernando, Denny Pee
Greem, Tamothy A.
Robert A. Altenberg
Application Number:
JP2006532537A
Publication Date:
February 15, 2012
Filing Date:
May 03, 2004
Export Citation:
Assignee:
ABBOTT LABORATORIES
International Classes:
C07D263/56; A61P25/00; C07D209/14; C07D235/14; C07D277/64; C07D279/16; C07D401/04; C07D401/14; C07D403/04; C07D403/06; C07D403/14; C07D405/04; C07D405/14; C07D413/06; C07D417/04; C07D417/06; C07D417/14; A61K31/404; A61K31/4184; A61K31/423; A61K31/428; A61K31/4439; A61K31/454; A61K31/4709; A61K31/506; A61K31/55; A61P1/04; A61P1/08; A61P3/00; A61P3/04; A61P3/10; A61P5/50; A61P9/10; A61P11/06; A61P15/08; A61P17/00; A61P25/06; A61P25/08; A61P25/16; A61P25/18; A61P25/20; A61P25/24; A61P25/28; A61P25/36; A61P29/00; A61P31/04; A61P35/00; A61P43/00; C07D235/10
Foreign References:
| WO2002074036A1 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura