Title:
ＭＧＡＴ２阻害活性を有する縮合環誘導体
Document Type and Number:
Japanese Patent JP7060298
Kind Code:
B1
Abstract:
本発明は、以下の式（Ｉ）で示される化合物を提供する。TIFF0007060298000140.tif4451（式中、TIFF0007060298000141.tif3385ｙは０または１であり；Ｒ１は水素等であり；Ｒ２ａおよびＲ２ｂは、隣接する炭素原子と一緒になって、環Ｂを形成し；環Ｂは置換もしくは非置換の非芳香族炭素環等であり；Ｒ３ａは水素等であり；Ｒ３ｂは水素等であり；Ｒ４ａは、式：TIFF0007060298000142.tif1132Ｌ１は単結合等であり；Ｌ２は－Ｃ（＝Ｏ）－等であり；Ｌ３は単結合等であり；Ｒ７は置換もしくは非置換のアルキル等であり；Ｒ４ｂは置換もしくは非置換のアルキル等であり；Ｒ４ｃはそれぞれ独立して、ハロゲン等である）【選択図】なし
Inventors:
Kohei Nozu
Yusuke Tateno
Kengo Masuda
Yuji Nishiura
Yoshikazu Sasaki
Yu Hinata
Yusuke Tateno
Kengo Masuda
Yuji Nishiura
Yoshikazu Sasaki
Yu Hinata
Application Number:
JP2022027456A
Publication Date:
April 26, 2022
Filing Date:
February 25, 2022
Export Citation:
Assignee:
Shionogi Pharmaceutical Co., Ltd.
International Classes:
C07D471/04; C07D491/20
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Other References:
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BUSUJIMA Tsuyoshi, et al.,Identification of 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-,Bioorganic & Medicinal Chemistry,2015年,Vol.23,p.5922-5931
SATO Kenjiro, et al.,Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA:monoacylglycerol acy,Bioorganic & Medicinal Chemistry,2015年,Vol.23,p.4544-4560
OKUMA Chihiro, et al.,JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevent,European Journal of Pharmacology,2015年,Vol.758,p.72-81
SATO Kenjiro, et al.,Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and,Journal of Medicinal Chemistry,2015年,Vol.58,p.3892-3909
MA Zhengping, et al.,Characterization of monoacylglycerol acyltransferase 2 inhibitors by a novel probe in binding assays,Analytical Biochemistry,2016年,Vol.501,p.48-55
BUSUJIMA Tsuyoshi, et al.,Identification of 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-,Bioorganic & Medicinal Chemistry,2015年,Vol.23,p.5922-5931
SATO Kenjiro, et al.,Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA:monoacylglycerol acy,Bioorganic & Medicinal Chemistry,2015年,Vol.23,p.4544-4560
OKUMA Chihiro, et al.,JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevent,European Journal of Pharmacology,2015年,Vol.758,p.72-81
SATO Kenjiro, et al.,Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and,Journal of Medicinal Chemistry,2015年,Vol.58,p.3892-3909
MA Zhengping, et al.,Characterization of monoacylglycerol acyltransferase 2 inhibitors by a novel probe in binding assays,Analytical Biochemistry,2016年,Vol.501,p.48-55
Attorney, Agent or Firm:
Kenichi Sugita
Hideaki Watanabe
Ayako Ochiai
Hideaki Watanabe
Ayako Ochiai