Title:
縮合イミダゾール化合物及び糖尿病治療薬
Document Type and Number:
Japanese Patent JP4324338
Kind Code:
B2
Abstract:
The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action. That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, is effective for preventing or treating diabetes mellitus and diabetic complications, and is represented by the formula (I): (wherein R<1> represents e.g. an amino group which may be substituted with an alkyl group; R<2> represents e.g. hydrogen atom, an alkyl group, a cycloalkyl group or an alkyl group, alkenyl group or alkynyl group which may be substituted with hydrox etc.; R<3> represents e.g. an optionally substituted alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, pyridinone group, pyrimidinone group or piperadinone group; Ar represents e.g. an optionally substituted aryl or heteroaryl group; and Q and W are the same as or different from each other and each represents N or CH), a pharmacologically acceptable salt or hydrates thereof.
Inventors:
Osamu Asano
Harada Hitoshi
Seiji Yoshikawa
Nobuhisa Watanabe
Kei Inoue
Tatsuo Horizoe
Nobuyuki Yasuda
Kaya Ohashi
Hiroe Minami
Junsaku Nagaoka
Manabu Murakami
Seiichi Kobayashi
Isao Tanaka
Kawada Riki
Naoyuki Shimomura
Akamatsu Hiroshi
Naoki Ozeki
Juichi Shimizu
Kenji Hayashi
Towakazu Hoshige
Shigeto Negi
Toshihiko Naito
Harada Hitoshi
Seiji Yoshikawa
Nobuhisa Watanabe
Kei Inoue
Tatsuo Horizoe
Nobuyuki Yasuda
Kaya Ohashi
Hiroe Minami
Junsaku Nagaoka
Manabu Murakami
Seiichi Kobayashi
Isao Tanaka
Kawada Riki
Naoyuki Shimomura
Akamatsu Hiroshi
Naoki Ozeki
Juichi Shimizu
Kenji Hayashi
Towakazu Hoshige
Shigeto Negi
Toshihiko Naito
Application Number:
JP2001507837A
Publication Date:
September 02, 2009
Filing Date:
June 30, 2000
Export Citation:
Assignee:
Eisai R & D Management Co., Ltd.
International Classes:
C07D473/34; A61K31/437; A61K31/52; A61K31/522; A61P3/10; A61P43/00; C07D213/73; C07D213/75; C07D235/18; C07D239/48; C07D471/04; C07D471/08; C07D473/00; C07D473/16; C07D473/18; C07D473/40; C07D487/04
Domestic Patent References:
| JPH02306916A | 1990-12-20 | |||
| JPH07243069A | 1995-09-19 | |||
| JPH11263789A | 1999-09-28 | |||
| JPH10182636A | 1998-07-07 | |||
| JPS60260579A | 1985-12-23 | |||
| JPS5441331A | 1979-04-02 | |||
| JPS62292782A | 1987-12-19 |
Foreign References:
| WO1998039344A1 | 1998-09-11 | |||
| US4714762A | 1987-12-22 | |||
| GB1004073A | 1965-09-08 | |||
| WO1997037072A1 | 1997-10-09 | |||
| WO1999057103A1 | 1999-11-11 | |||
| US3155571A | 1964-11-03 | |||
| US5552426A | 1996-09-03 | |||
| WO1997033873A1 | 1997-09-18 |
Other References:
MUTATION RESEARCH, vol. 263, JPN7008001747, 1991, pages 93 - 100, ISSN: 0000989947
J. MED. CHEM., vol. 42, JPN6008009237, 1999, pages 833 - 848, ISSN: 0000989948
J. MED. CHEM., vol. 33, JPN6008009239, 1990, pages 2073 - 2080, ISSN: 0000989946
J. MED. CHEM., vol. 42, JPN6008009237, 1999, pages 833 - 848, ISSN: 0000989948
J. MED. CHEM., vol. 33, JPN6008009239, 1990, pages 2073 - 2080, ISSN: 0000989946
Attorney, Agent or Firm:
Satoshi Furuya
Takahiko Mizobe
Shinji Mochida
Yoshitsune Kazumasa
Takahiko Mizobe
Shinji Mochida
Yoshitsune Kazumasa
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