Title:
ＴＮＦ活性のモジュレーターとしての縮合三環式ベンゾイミダゾール誘導体
Document Type and Number:
Japanese Patent JP6573614
Kind Code:
B2
Abstract:
A series of tricyclic benzimidazole derivatives, in particular dihydro-1H-imidazo [1,2-a]benzimidazole, dihydro-1H-pyrrolo [1,2-a]benzimidazole, dihydro-1H-pyrazino[1,2-a]benzimidazole, dihydro-1H-[1,4]oxazino[4,3-a]benzimidazole and dihydrothiazolo[3,4-a]benzimidazolem, and analogs thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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Inventors:
Alexander, Ricky Peter
Carmiano, Mark, Daniel
Defy, Sabine
Dryu, Veronique
Deligney, Michael
Hale, Yak Paul
Jackson, Victoria Elizabeth
Key Aalto, Jean
Croprian, Boris
Maccos, Malcolm
Subnis, Yogesh Anil
Selby, Matthew Duncan
Swinen, Dominique Louis Leon
Fan Hout Fin, Natalie
Chu, Chaonin
Wehner, Volkmal
Heinert, Uwe
Carmiano, Mark, Daniel
Defy, Sabine
Dryu, Veronique
Deligney, Michael
Hale, Yak Paul
Jackson, Victoria Elizabeth
Key Aalto, Jean
Croprian, Boris
Maccos, Malcolm
Subnis, Yogesh Anil
Selby, Matthew Duncan
Swinen, Dominique Louis Leon
Fan Hout Fin, Natalie
Chu, Chaonin
Wehner, Volkmal
Heinert, Uwe
Application Number:
JP2016537495A
Publication Date:
September 11, 2019
Filing Date:
December 08, 2014
Export Citation:
Assignee:
UCB Biopharma SPR L
International Classes:
C07D471/04; A61K31/4184; A61K31/4188; A61K31/429; A61K31/437; A61K31/438; A61K31/4439; A61K31/4985; A61K31/5377; A61K31/5383; A61K31/5386; A61K31/551; A61P3/00; A61P9/00; A61P25/00; A61P25/04; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P43/00; C07D487/04; C07D498/04; C07D513/04; C07D519/00
Domestic Patent References:
| JP2016539958A |
Other References:
Arch. Pharm. Pharm. Med. Chem.,2001年,334,203-208
Biochemical and Biophysical Research Communications,2007年,353,628-632
Antiviral Chemistry & Chemotherapy,1999年,10,211-217
IL FARMACO,1996年,51(4),279-282
Journal of Virology,2008年,82(10),4720-4730
E-Journal of Chemistry,2011年,8(2),748-752
Biochemical and Biophysical Research Communications,2007年,353,628-632
Antiviral Chemistry & Chemotherapy,1999年,10,211-217
IL FARMACO,1996年,51(4),279-282
Journal of Virology,2008年,82(10),4720-4730
E-Journal of Chemistry,2011年,8(2),748-752
Attorney, Agent or Firm:
Asamura patent office